FCRL6 Fc receptor like 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FCRL6provided by HGNC
Official Full Name: Fc receptor like 6provided by HGNC
Primary source: HGNC:HGNC:31910
See related: Ensembl:ENSG00000181036 MIM:613562; AllianceGenome:HGNC:31910
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FcRH6
Summary: Enables MHC class II protein binding activity and protein phosphatase binding activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen (RPKM 6.7), lung (RPKM 2.6) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q23.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (159800512..159816257)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (158937524..158953270)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (159770302..159786047)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human FCRL6 receptor, selectively expressed by cytotoxic T and natural killer (NK) cells, directly binds the major histocompatibility complex (MHC) class II molecule HLA-DR.
Title: Cutting edge: FcR-like 6 is an MHC class II receptor.
FCRL6 is a distinct indicator of cytotoxic effector lymphocytes that is upregulated in diseases characterized by chronic immune stimulation.
Title: FCRL6 distinguishes mature cytotoxic lymphocytes and is upregulated in patients with B-cell chronic lymphocytic leukemia.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat downregulates the expression of Fc receptor-like 6 (FCRL6) in human primary T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables MHC class II protein binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Fc receptor-like protein 6

Names: Fc receptor-like protein 7; IFGP6; IgSF type I transmembrane receptor; fc receptor homolog 6; fcR-like protein 6; leukocyte receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004310.3 → NP_001004310.2 Fc receptor-like protein 6 isoform 1 precursor

See identical proteins and their annotated locations for NP_001004310.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer protein (isoform 1).

Source sequence(s)

AI631310, AK131201, AL590560, AY513661, DA959587

Consensus CDS

CCDS30912.1

UniProtKB/Swiss-Prot

A1KXW6, A2A4D6, Q6DN72, Q6DN73, Q6XRC3, Q6ZNI1

Related

ENSP00000357086.3, ENST00000368106.4

Conserved Domains (4) summary

cd05753
Location:19 → 98

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:123 → 198

IG_like; Immunoglobulin like

pfam13895
Location:112 → 200

Ig_2; Immunoglobulin domain

pfam13927
Location:206 → 280

Ig_3; Immunoglobulin domain
NM_001284217.2 → NP_001271146.1 Fc receptor-like protein 6 isoform 2 precursor

See identical proteins and their annotated locations for NP_001271146.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus.

Source sequence(s)

AI631310, AK131201

Consensus CDS

CCDS60312.1

UniProtKB/Swiss-Prot

Q6DN72

Related

ENSP00000320625.6, ENST00000321935.10

Conserved Domains (4) summary

cd05753
Location:26 → 105

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:130 → 205

IG_like; Immunoglobulin like

pfam13895
Location:119 → 207

Ig_2; Immunoglobulin domain

pfam13927
Location:213 → 287

Ig_3; Immunoglobulin domain
NM_001426231.1 → NP_001413160.1 Fc receptor-like protein 6 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL590560
NM_001426232.1 → NP_001413161.1 Fc receptor-like protein 6 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AL590560
NM_001426233.1 → NP_001413162.1 Fc receptor-like protein 6 isoform 5

Status: VALIDATED

Source sequence(s)

AL590560
NM_001426234.1 → NP_001413163.1 Fc receptor-like protein 6 isoform 6 precursor

Status: VALIDATED

Source sequence(s)

AL590560

Related

ENSP00000340949.5, ENST00000339348.9
NM_001426235.1 → NP_001413164.1 Fc receptor-like protein 6 isoform 7 precursor

Status: VALIDATED

Source sequence(s)

CP068277
NM_001426236.1 → NP_001413165.1 Fc receptor-like protein 6 isoform 8 precursor

Status: VALIDATED

Source sequence(s)

CP068277
NM_001426237.1 → NP_001413166.1 Fc receptor-like protein 6 isoform 9

Status: VALIDATED

Source sequence(s)

CP068277