U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

lft lowfat [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34405, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
lftprovided by FlyBase
Official Full Name
lowfatprovided by FlyBase
Primary source
FLYBASE:FBgn0032230
Locus tag
Dmel_CG13139
See related
AllianceGenome:FB:FBgn0032230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13139; Dmel\CG13139; Lft; LFT
Summary
Involved in imaginal disc-derived wing morphogenesis. Located in cytoplasm. Part of subapical complex. Is expressed in embryonic/larval optic lobe and imaginal disc. Orthologous to several human genes including LIX1L (limb and CNS expressed 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See lft in Genome Data Viewer
Location:
31D10-31D10; 2-41 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10364471..10366410)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10364471..10366410)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cullin-associated and neddylation-dissociated 1 Neighboring gene pimples Neighboring gene uncharacterized protein Neighboring gene rhomboid-5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins. Gridnev A, et al. Front Cell Dev Biol, 2022. PMID 35372364, Free PMC Article
  2. Drosophila lowfat, a novel modulator of Fat signaling. Mao Y, et al. Development, 2009 Oct. PMID 19710173, Free PMC Article
  3. Two frizzled planar cell polarity signals in the Drosophila wing are differentially organized by the Fat/Dachsous pathway. Hogan J, et al. PLoS Genet, 2011 Feb. PMID 21379328, Free PMC Article
  4. Sleeping giants: emerging roles for the fat cadherins in health and disease. Sadeqzadeh E, et al. Med Res Rev, 2014 Jan. PMID 23720094
  5. Hippo signaling: growth control and beyond. Halder G, et al. Development, 2011 Jan. PMID 21138973, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of subapical complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
lowfat
Names
CG13139-PA
CG13139-PB
Low fat
lft-PA
lft-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10364471..10366410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201846.2 → NP_001188775.1  lowfat, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188775.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VKY1
    Conserved Domains (1) summary
    pfam14954
    Location:24 → 255
    LIX1; Limb expression 1

  2. NM_135546.3 → NP_609390.1  lowfat, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609390.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VKY1
    Related
    FBpp0079592
    Conserved Domains (1) summary
    pfam14954
    Location:24 → 255
    LIX1; Limb expression 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKY1.1 Q9VKY1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous