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FOXI3 forkhead box I3 [ Homo sapiens (human) ]

Gene ID: 344167, updated on 10-Dec-2024

Summary

Official Symbol
FOXI3provided by HGNC
Official Full Name
forkhead box I3provided by HGNC
Primary source
HGNC:HGNC:35123
See related
Ensembl:ENSG00000214336 MIM:612351; AllianceGenome:HGNC:35123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CFM2
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in pharyngeal system development. Is active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward placenta (RPKM 3.1) See more
Orthologs
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Genomic context

See FOXI3 in Genome Data Viewer
Location:
2p11.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (88446787..88452693, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (88458787..88464693, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (88746306..88752211, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:88715589-88716195 Neighboring gene RNA, U6 small nuclear 1007, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:88741313-88741813 Neighboring gene RPL38 pseudogene 6 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:88743237-88743870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:88743871-88744504 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:88803591-88804790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:88811519-88812020 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:88817004-88817504 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:88817505-88818005 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:88837459-88838658 Neighboring gene uncharacterized LOC101928371 Neighboring gene sperm microtubule inner protein 9 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epidermal cell fate specification ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hair follicle development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in odontogenesis of dentin-containing tooth ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in otic placode development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in parathyroid gland development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pharyngeal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in thymus development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135649.3NP_001129121.1  forkhead box protein I3

    See identical proteins and their annotated locations for NP_001129121.1

    Status: VALIDATED

    Source sequence(s)
    AA349674, AC012671, AI201229, KF459612
    Consensus CDS
    CCDS77433.1
    UniProtKB/Swiss-Prot
    A8MTJ6, B5RI09
    Related
    ENSP00000478384.2, ENST00000428390.3
    Conserved Domains (1) summary
    pfam00250
    Location:145231
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    88446787..88452693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    88458787..88464693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)