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IGFBP6 insulin like growth factor binding protein 6 [ Homo sapiens (human) ]

Gene ID: 3489, updated on 27-Nov-2024

Summary

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Official Symbol
IGFBP6provided by HGNC
Official Full Name
insulin like growth factor binding protein 6provided by HGNC
Primary source
HGNC:HGNC:5475
See related
Ensembl:ENSG00000167779 MIM:146735; AllianceGenome:HGNC:5475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IBP6
Summary
Enables identical protein binding activity and insulin-like growth factor II binding activity. Involved in cell migration and positive regulation of stress-activated MAPK cascade. Part of insulin-like growth factor binary complex. Implicated in obesity. Biomarker of breast cancer; in situ carcinoma; leiomyoma; and neovascular inflammatory vitreoretinopathy. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in fat (RPKM 60.7), prostate (RPKM 49.9) and 17 other tissues See more
Orthologs
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Genomic context

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See IGFBP6 in Genome Data Viewer
Location:
12q13.13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (53097667..53102340)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (53062042..53066717)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53491451..53496124)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene tensin 2 Neighboring gene microRNA 6757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53459723-53460224 Neighboring gene SPRY domain containing 3 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr12:53465666-53466166 and GRCh37_chr12:53466167-53466667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4493 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4494 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:53493256-53493471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53496852-53497380 Neighboring gene uncharacterized LOC124902936 Neighboring gene sterol O-acyltransferase 2 Neighboring gene vesicle transport through interaction with t-SNAREs 1B pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation. Yu H, et al. J Clin Lab Anal, 1999. PMID 10414596, Free PMC Article
  2. IGFBP6 is a novel nasopharyngeal carcinoma prognostic biomarker. Chen Q, et al. Oncotarget, 2016 Oct 18. PMID 27623076, Free PMC Article
  3. Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II. Roghani M, et al. FEBS Lett, 1989 Sep 25. PMID 2551732
  4. A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-beta and insulin-like growth factor binding protein-6, in a calcium- and cell density-dependent manner. Kato M, et al. J Biol Chem, 1995 May 26. PMID 7539002
  5. Downregulation of Insulin-like growth factor binding protein 6 is associated with ACTH-secreting pituitary adenoma growth. Yang Y, et al. Pituitary, 2014 Dec. PMID 24379119

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prognostic Value of IGFBP6 in Breast Cancer: Focus on Glucometabolism.
    Title: Prognostic Value of IGFBP6 in Breast Cancer: Focus on Glucometabolism.
  2. Evaluation of SNPs from human IGFBP6 associated with gene expression: an in-silico study.
    Title: Evaluation of SNPs from human IGFBP6 associated with gene expression: an in-silico study.
  3. Effect of IGFBP6 Knockdown on Proteins Regulating Exosome Synthesis and Secretion in MDA-MB-231 Cell Line.
    Title: Effect of IGFBP6 Knockdown on Proteins Regulating Exosome Synthesis and Secretion in MDA-MB-231 Cell Line.
  4. Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma.
    Title: Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma.
  5. MAFB promotes the malignant phenotypes by IGFBP6 in esophageal squamous cell carcinomas.
    Title: MAFB promotes the malignant phenotypes by IGFBP6 in esophageal squamous cell carcinomas.
  6. IGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis.
    Title: IGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis.
  7. The clinical characteristics and prognostic value of IGFBP6 in glioma.
    Title: The clinical characteristics and prognostic value of IGFBP6 in glioma.
  8. IGFBP6 Is Downregulated in Unstable Carotid Atherosclerotic Plaques According to an Integrated Bioinformatics Analysis and Experimental Verification.
    Title: IGFBP6 Is Downregulated in Unstable Carotid Atherosclerotic Plaques According to an Integrated Bioinformatics Analysis and Experimental Verification.
  9. Decreased expression of IGFBP6 correlates with poor survival in colorectal cancer patients.
    Title: Decreased expression of IGFBP6 correlates with poor survival in colorectal cancer patients.
  10. IGFBP-6 seems to play an important role in the control of cell-specific immunologic adaptation following hyperthermia. (Review)
    Title: From fever to immunity: A new role for IGFBP-6?
Submit: New GeneRIF Correction See all GeneRIFs (56)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection downregulates IGFBP6 expression in CEM*174 cells and mixed PBMC from HIV infected patients PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fibronectin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin-like growth factor II binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of insulin-like growth factor binary complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
insulin-like growth factor-binding protein 6
Names
IBP-6
IGF binding protein 6
IGFBP-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002178.3 → NP_002169.1  insulin-like growth factor-binding protein 6 precursor

    See identical proteins and their annotated locations for NP_002169.1

    Status: VALIDATED

    Source sequence(s)
    BQ925731, M69054
    Consensus CDS
    CCDS8846.1
    UniProtKB/Swiss-Prot
    P24592, Q14492
    UniProtKB/TrEMBL
    F8VYK9
    Related
    ENSP00000301464.3, ENST00000301464.4
    Conserved Domains (2) summary
    smart00121
    Location:27 → 105
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:163 → 234
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    53097667..53102340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428786.1 → XP_047284742.1  insulin-like growth factor-binding protein 6 isoform X1

    UniProtKB/TrEMBL
    F8VVA5
    Related
    ENSP00000449344.1, ENST00000548176.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    53062042..53066717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371954.1 → XP_054227929.1  insulin-like growth factor-binding protein 6 isoform X1

    UniProtKB/TrEMBL
    F8VVA5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24592.1 GenPept UniProtKB/Swiss-Prot:P24592

Gene LinkOut

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