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Idgf2 Imaginal disc growth factor 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34979, updated on 18-Sep-2024

Summary

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Official Symbol
Idgf2provided by FlyBase
Official Full Name
Imaginal disc growth factor 2provided by FlyBase
Primary source
FLYBASE:FBgn0020415
Locus tag
Dmel_CG4475
See related
AllianceGenome:FB:FBgn0020415
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS02780.4; CG4475; Dmel\CG4475; DmIDGF2; IDGF; IDGF-2; idgf2; IDGF2; ldgf2
Summary
Enables imaginal disc growth factor receptor binding activity. Involved in imaginal disc development; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including circulatory system; egg chamber; embryonic/larval brain; gastrula embryo; and yolk. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1); CHI3L1 (chitinase 3 like 1); and CHI3L2 (chitinase 3 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Idgf2 in Genome Data Viewer
Location:
36A1-36A1; 2-52 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16447330..16450508)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16447330..16450508)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene juvenile hormone acid methyltransferase Neighboring gene uncharacterized protein Neighboring gene Imaginal disc growth factor 1 Neighboring gene Imaginal disc growth factor 3 Neighboring gene dachshund

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification, and innate immunity. Broz V, et al. Sci Rep, 2017 Feb 23. PMID 28230183, Free PMC Article
  2. The Imaginal Disc Growth Factors 2 and 3 participate in the Drosophila response to nematode infection. Yadav S, et al. Parasite Immunol, 2018 Oct. PMID 30107045
  3. Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism. Towler BP, et al. PLoS Genet, 2020 Dec. PMID 33370287, Free PMC Article
  4. Crystal structure of imaginal disc growth factor-2. A member of a new family of growth-promoting glycoproteins from Drosophila melanogaster. Varela PF, et al. J Biol Chem, 2002 Apr 12. PMID 11821393
  5. Imaginal disk growth factors are Drosophila chitinase-like proteins with roles in morphogenesis and CO2 response. Sustar AE, et al. Genetics, 2023 Feb 9. PMID 36576887, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results indicate that Idgf2 and Idgf3 might be involved in different yet crucial immune functions in the Drosophila anti-nematode immune response. Idgf2 and Idgf3 modulate distinct immune functions in Drosophila larvae in response to Steinernema nematode infection.
    Title: The Imaginal Disc Growth Factors 2 and 3 participate in the Drosophila response to nematode infection.
  2. These findings provide evidence that IDGF2 is an important trophic factor promoting cellular and organismal survival.
    Title: Drosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification, and innate immunity.
  3. ifferential mass spectrometry analysis of these cells detected elevated levels of four of the six Idgf family members (Idgf1, Idgf2, Idgf4, and Idgf6) in flies mutant for bullwinkle (bwk), which encodes a transcription factor and is a known regulator of DA-tube morphogenesis. We show that, during oogenesis, dysregulation of Idgfs (either gain or loss of function) disrupts the formation of the DA tubes
    Title: Proteomics Analysis Identifies Orthologs of Human Chitinase-Like Proteins as Inducers of Tube Morphogenesis Defects in Drosophila melanogaster.
  4. determination of cystal structure
    Title: Crystal structure of imaginal disc growth factor-2. A member of a new family of growth-promoting glycoproteins from Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables imaginal disc growth factor receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in imaginal disc development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
imaginal disc growth factor 2
Names
CG4475-PA
CG4475-PB
CG4475-PC
Idgf2-PA
Idgf2-PB
Idgf2-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16447330..16450508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259114.2 → NP_001246043.1  imaginal disc growth factor 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246043.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D4G7B1
    Conserved Domains (2) summary
    cd02873
    Location:1 → 368
    GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
    smart00636
    Location:2 → 347
    Glyco_18; Glyco_18 domain

  2. NM_057909.5 → NP_477257.2  imaginal disc growth factor 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477257.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96665, Q9V3D4
    Related
    FBpp0080418
    Conserved Domains (1) summary
    cd02873
    Location:23 → 440
    GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...

  3. NM_001259113.2 → NP_001246042.1  imaginal disc growth factor 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246042.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D4G7B1
    Conserved Domains (2) summary
    cd02873
    Location:1 → 368
    GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
    smart00636
    Location:2 → 347
    Glyco_18; Glyco_18 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4G7B1 D4G7B1
Q9V3D4.1 Q9V3D4

Gene LinkOut

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