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txnrd3 thioredoxin reductase 3 [ Danio rerio (zebrafish) ]

Gene ID: 352924, updated on 4-Jan-2025

Summary

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Official Symbol
txnrd3provided by ZNC
Official Full Name
thioredoxin reductase 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030327-3
See related
Ensembl:ENSDARG00000100374 AllianceGenome:ZFIN:ZDB-GENE-030327-3
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
TrxR1; TrxR2; cb682; cb683; txnrd1; fb83a08; wu:fb83a08
Summary
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a TrxR isozyme similar to the third mammalian TrxR, which contains an additional N-terminal glutaredoxin (Grx) domain. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Feb 2018]
Orthologs
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Genomic context

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See txnrd3 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (1161224..1187749, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (661722..688088, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495905 Neighboring gene zinc finger E-box binding homeobox 2b Neighboring gene NACHT, LRR and PYD domains-containing protein 3-like Neighboring gene plexin A1b Neighboring gene uncharacterized LOC100538256

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish (Danio rerio) vary by strain and sex in their behavioral and transcriptional responses to selenium supplementation. Benner MJ, et al. Comp Biochem Physiol A Mol Integr Physiol, 2010 Dec. PMID 20659579, Free PMC Article
  2. The expression of essential selenoproteins during development requires SECIS-binding protein 2-like. Kiledjian NT, et al. Life Sci Alliance, 2022 May. PMID 35210313, Free PMC Article
  3. Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Facchinello N, et al. Cell Death Dis, 2021 Jan 19. PMID 33469036, Free PMC Article
  4. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems. Sun QA, et al. Proc Natl Acad Sci U S A, 2001 Mar 27. PMID 11259642, Free PMC Article
  5. Roles of selenoprotein antioxidant protection in zebrafish, Danio rerio, subjected to dietary oxidative stress. Betancor MB, et al. Fish Physiol Biochem, 2015 Jun. PMID 25750091

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thioredoxin reductase 3
NP_898895.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183072.2 → NP_898895.2  thioredoxin reductase 3

    Status: REVIEWED

    Source sequence(s)
    BC054599, CABZ01063040, EB861362
    UniProtKB/TrEMBL
    A0A8M1PCD1
    Related
    ENSDARP00000135844.2, ENSDART00000172544.3
    Conserved Domains (5) summary
    cd03419
    Location:25 → 106
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
    TIGR01438
    Location:114 → 602
    TGR; thioredoxin and glutathione reductase selenoprotein
    pfam00070
    Location:295 → 371
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:474 → 584
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    cl21454
    Location:114 → 160
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    1161224..1187749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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