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cntn1a contactin 1a [ Danio rerio (zebrafish) ]

Gene ID: 353150, updated on 4-Jan-2025

Summary

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Official Symbol
cntn1aprovided by ZNC
Official Full Name
contactin 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030427-1
See related
AllianceGenome:ZFIN:ZDB-GENE-030427-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
F3; cntn1
Summary
Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in axon guidance; brain development; and cell-cell adhesion. Predicted to act upstream of or within cell adhesion. Predicted to be located in side of membrane. Predicted to be active in axon and plasma membrane. Is expressed in heart; musculature system; and nervous system. Human ortholog(s) of this gene implicated in Compton-North congenital myopathy. Orthologous to human CNTN1 (contactin 1). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See cntn1a in Genome Data Viewer
Location:
chromosome: 25
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (5109..147882)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (57465..180145)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene calcium-independent phospholipase A2-gamma Neighboring gene uncharacterized LOC137489302 Neighboring gene uncharacterized LOC137489303 Neighboring gene uncharacterized LOC110438374 Neighboring gene uncharacterized LOC108181599 Neighboring gene hepatic triacylglycerol lipase Neighboring gene disintegrin and metalloproteinase domain-containing protein 10-like Neighboring gene PCNA clamp associated factor Neighboring gene neuronal cell adhesion molecule b Neighboring gene ADAM metallopeptidase domain 10b Neighboring gene von Willebrand factor A domain-containing protein 5A-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of the zebrafish recognition molecule F3/F11/contactin in a subset of differentiating neurons is regulated by cofactors associated with LIM domains. Gimnopoulos D, et al. Mech Dev, 2002 Dec. PMID 14516675
  2. Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination. Takeuchi M, et al. Genes Cells, 2017 Aug. PMID 28639422
  3. Myelination induces axonal hotspots of synaptic vesicle fusion that promote sheath growth. Almeida RG, et al. Curr Biol, 2021 Sep 13. PMID 34270947, Free PMC Article
  4. The neuronal growth and regeneration associated Cntn1 (F3/F11/Contactin) gene is duplicated in fish: expression during development and retinal axon regeneration. Haenisch C, et al. Mol Cell Neurosci, 2005 Feb. PMID 15691716
  5. Contactin1a expression is associated with oligodendrocyte differentiation and axonal regeneration in the central nervous system of zebrafish. Schweitzer J, et al. Mol Cell Neurosci, 2007 Jun. PMID 17425960

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The complex regulation patterns suggest roles for Cntn1a in myelinating cells and neurons particularly in successful CNS regeneration.
    Title: Contactin1a expression is associated with oligodendrocyte differentiation and axonal regeneration in the central nervous system of zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
contactin-1a
Names
F3/F11/contactin
neural cell recognition molecule F11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_180969.2 → NP_851300.2  contactin-1a precursor

    See identical proteins and their annotated locations for NP_851300.2

    Status: PROVISIONAL

    Source sequence(s)
    CU458969
    UniProtKB/Swiss-Prot
    Q8AXZ4
    UniProtKB/TrEMBL
    A4JYP8
    Conserved Domains (6) summary
    cd04969
    Location:440 → 511
    Ig5_Contactin_like; Fifth Ig domain of contactin
    smart00060
    Location:825 → 905
    FN3; Fibronectin type 3 domain
    smart00410
    Location:256 → 336
    IG_like; Immunoglobulin like
    cd00063
    Location:627 → 714
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:423 → 511
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:142 → 237
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    5109..147882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8AXZ4.1 GenPept UniProtKB/Swiss-Prot:Q8AXZ4

Gene LinkOut

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