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Clec18a C-type lectin domain family 18, member A [ Mus musculus (house mouse) ]

Gene ID: 353287, updated on 28-Oct-2024

Summary

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Official Symbol
Clec18aprovided by MGI
Official Full Name
C-type lectin domain family 18, member Aprovided by MGI
Primary source
MGI:MGI:2672935
See related
Ensembl:ENSMUSG00000033633 AllianceGenome:MGI:2672935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mrcl
Summary
Predicted to enable polysaccharide binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CLEC18A (C-type lectin domain family 18 member A); CLEC18B (C-type lectin domain family 18 member B); and CLEC18C (C-type lectin domain family 18 member C). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in cortex adult (RPKM 1.7), frontal lobe adult (RPKM 1.2) and 9 other tissues See more
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Genomic context

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See Clec18a in Genome Data Viewer
Location:
8 E1; 8 57.93 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111796128..111819056, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111069496..111092424, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene predicted gene, 38523 Neighboring gene nuclear encoded tRNA glycine 2 (anticodon GCC) Neighboring gene exosome component 6 Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit Neighboring gene RIKEN cDNA 9430091E24 gene Neighboring gene golgi apparatus protein 1 Neighboring gene STARR-seq mESC enhancer starr_22692 Neighboring gene STARR-positive B cell enhancer ABC_E708 Neighboring gene predicted gene, 53455

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection. Huang YL, et al. Commun Biol, 2021 Feb 18. PMID 33603190, Free PMC Article
  2. The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation. Burgdorf S, et al. J Immunol, 2006 Jun 1. PMID 16709836
  3. Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling. Gerber SD, et al. PLoS One, 2012. PMID 22432025, Free PMC Article
  4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.
    Title: Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.
  2. Dendritic cells use the mannose receptor for endocytosis of a particular antigen type (soluble ovalbumin) intended for cross-presentation.
    Title: The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables polysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polysaccharide binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
C-type lectin domain family 18 member A
Names
mannose receptor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402947.1 → NP_001389876.1  C-type lectin domain family 18 member A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093451

  2. NM_181549.4 → NP_853527.2  C-type lectin domain family 18 member A isoforn 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC093451
    UniProtKB/TrEMBL
    A0A087WP55
    Related
    ENSMUSP00000141073.2, ENSMUST00000188466.7
    Conserved Domains (2) summary
    cd00037
    Location:316 → 440
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd05380
    Location:55 → 189
    SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    111796128..111819056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248418.2 → XP_011246720.1  C-type lectin domain family 18 member A isoform X6

    Conserved Domains (2) summary
    cd00037
    Location:390 → 514
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd05380
    Location:129 → 263
    CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

  2. XM_006531143.3 → XP_006531206.3  C-type lectin domain family 18 member A isoform X7

    UniProtKB/TrEMBL
    A0A087WP55
    Related
    ENSMUSP00000139569.2, ENSMUST00000191030.7
    Conserved Domains (2) summary
    cd00037
    Location:368 → 492
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd05380
    Location:107 → 241
    CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

  3. XM_030243639.2 → XP_030099499.1  C-type lectin domain family 18 member A isoform X3

    Conserved Domains (3) summary
    cd00037
    Location:359 → 483
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd00054
    Location:305 → 341
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05380
    Location:129 → 263
    CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

  4. XM_030243637.2 → XP_030099497.1  C-type lectin domain family 18 member A isoform X1

    Conserved Domains (3) summary
    cd00037
    Location:390 → 514
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00180
    Location:315 → 360
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd05380
    Location:129 → 263
    CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

  5. XM_030243641.2 → XP_030099501.1  C-type lectin domain family 18 member A isoform X5

    Conserved Domains (2) summary
    cd00037
    Location:337 → 461
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd05380
    Location:76 → 210
    CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

  6. XM_030243638.2 → XP_030099498.1  C-type lectin domain family 18 member A isoform X2

    Conserved Domains (3) summary
    cd00037
    Location:368 → 492
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00180
    Location:293 → 338
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd05380
    Location:107 → 241
    CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

  7. XM_030243642.2 → XP_030099502.1  C-type lectin domain family 18 member A isoform X8

    Conserved Domains (2) summary
    cd00037
    Location:243 → 367
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd05380
    Location:1 → 116
    CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

  8. XM_030243640.2 → XP_030099500.1  C-type lectin domain family 18 member A isoform X4

    UniProtKB/Swiss-Prot
    Q7TMA7, Q7TSP9, Q7TSQ0, Q7TSQ1, Q7TSQ7
    Conserved Domains (2) summary
    cd00037
    Location:341 → 465
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd05380
    Location:80 → 214
    CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

  9. XM_011248419.2 → XP_011246721.1  C-type lectin domain family 18 member A isoform X9

    UniProtKB/TrEMBL
    A0A087WP55
    Conserved Domains (1) summary
    cd05380
    Location:129 → 263
    CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSQ1.1 GenPept UniProtKB/Swiss-Prot:Q7TSQ1

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