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LILRA5 leukocyte immunoglobulin like receptor A5 [ Homo sapiens (human) ]

Gene ID: 353514, updated on 2-Nov-2024

Summary

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Official Symbol
LILRA5provided by HGNC
Official Full Name
leukocyte immunoglobulin like receptor A5provided by HGNC
Primary source
HGNC:HGNC:16309
See related
Ensembl:ENSG00000187116 MIM:606047; AllianceGenome:HGNC:16309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD85; LIR9; CD85F; ILT11; LIR-9; ILT-11; LILRB7
Summary
The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in appendix (RPKM 29.5), bone marrow (RPKM 22.9) and 4 other tissues See more
Orthologs
all
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Genomic context

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See LILRA5 in Genome Data Viewer
Location:
19q13.42
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54307070..54313166, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57396884..57402937, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54818353..54824436, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54778410-54779374 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:54782879-54784078 Neighboring gene leukocyte immunoglobulin like receptor B2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54789309-54789810 Neighboring gene microRNA 4752 Neighboring gene MPRA-validated peak3552 silencer Neighboring gene vomeronasal 1 receptor 104 pseudogene Neighboring gene Sharpr-MPRA regulatory region 7396 Neighboring gene MPRA-validated peak3554 silencer Neighboring gene leukocyte immunoglobulin like receptor A4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Crystal structure of the human monocyte-activating receptor, "Group 2" leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11). Shiroishi M, et al. J Biol Chem, 2006 Jul 14. PMID 16675463
  2. LILRA5 is expressed by synovial tissue macrophages in rheumatoid arthritis, selectively induces pro-inflammatory cytokines and IL-10 and is regulated by TNF-alpha, IL-10 and IFN-gamma. Mitchell A, et al. Eur J Immunol, 2008 Dec. PMID 19009525
  3. LIR9, an immunoglobulin-superfamily-activating receptor, is expressed as a transmembrane and as a secreted molecule. Borges L, et al. Blood, 2003 Feb 15. PMID 12393390
  4. Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes. Jones DC, et al. Eur J Immunol, 2009 Nov. PMID 19658091
  5. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. Wende H, et al. Immunogenetics, 2000 Jul. PMID 10941842

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
  2. LILRA5/LIR9/ILT11 does not play a role in any MHCI recognition but could possibly bind to non-MHCI ligand(s) on the target cells to provide a novel immune regulation mechanism
    Title: Crystal structure of the human monocyte-activating receptor, "Group 2" leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11).
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: LILRA4

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of interleukin-13 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leukocyte immunoglobulin-like receptor subfamily A member 5
Names
CD85 antigen-like family member F
immunoglobulin-like transcript 11 protein
leucocyte Ig-like receptor A5
leukocyte Ig-like receptor 9
leukocyte immunoglobulin-like receptor 9
leukocyte immunoglobulin-like receptor subfamily A member 5 soluble
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021250.4 → NP_067073.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_067073.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as LIR9m1, encodes the longest isoform (1).
    Source sequence(s)
    AC245884, AF324830, AF499916
    Consensus CDS
    CCDS12888.1
    UniProtKB/Swiss-Prot
    A6NHI3, A6NI73
    UniProtKB/TrEMBL
    A0A0U4ARJ3
    Related
    ENSP00000404236.4, ENST00000432233.8
    Conserved Domains (2) summary
    cd05711
    Location:141 → 236
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:45 → 136
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins

  2. NM_181879.3 → NP_870994.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 3 precursor

    See identical proteins and their annotated locations for NP_870994.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as LIR9s1, differs in the 3' end-region, which includes a part of the coding region, as compared to variant 1. The resulting isoform (3) has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC245884, AF324830, AF499918, AF499919
    UniProtKB/Swiss-Prot
    A6NI73
    Related
    ENST00000446712.4
    Conserved Domains (2) summary
    cd05711
    Location:141 → 236
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:45 → 136
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins

  3. NM_181985.4 → NP_871714.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_871714.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as LIR9m2, lacks an in-frame coding segment, as compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    AC245884, AF324830, AF499917
    Consensus CDS
    CCDS12889.1
    UniProtKB/TrEMBL
    A0A0U4ARJ3
    Related
    ENSP00000484372.1, ENST00000486742.2
    Conserved Domains (2) summary
    cd05711
    Location:129 → 224
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:33 → 124
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins

  4. NM_181986.3 → NP_871715.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 4 precursor

    See identical proteins and their annotated locations for NP_871715.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as LIR9s2, lacks an in-frame coding segment and differs in the 3' end-region, as compared to variant 1. The resulting isoform (4) lacks an internal region and has a distinct and shorter C-terminus as compared to isoform 1.
    Source sequence(s)
    AC245884, AF324830, AF499919
    UniProtKB/Swiss-Prot
    A6NI73
    Related
    ENST00000489504.5
    Conserved Domains (2) summary
    cd05711
    Location:129 → 224
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:33 → 124
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    54307070..54313166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    288498..294581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    288422..294512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p14 ALT_REF_LOCI_8

    Range
    288603..294667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

    Range
    289467..295550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    57396884..57402937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NI73.1 GenPept UniProtKB/Swiss-Prot:A6NI73

Gene LinkOut

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