Gle1 Gle1 RNA export mediator [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gle1provided by FlyBase
Official Full Name: Gle1 RNA export mediatorprovided by FlyBase
Primary source: FLYBASE:FBgn0033316
Locus tag: Dmel_CG14749
See related: AllianceGenome:FB:FBgn0033316
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14749; Dmel\CG14749; Gle; GLE1
Summary: Predicted to enable inositol hexakisphosphate binding activity; phospholipid binding activity; and translation initiation factor binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus; regulation of translational initiation; and regulation of translational termination. Predicted to be part of nuclear pore cytoplasmic filaments. Predicted to be active in cytoplasm. Is expressed in organism and spermatozoon. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 1. Orthologous to human GLE1 (GLE1 RNA export mediator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8627900..8630186)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4515405..4517691)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables inositol hexakisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in poly(A)+ mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear pore cytoplasmic filaments	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain