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IL10RA interleukin 10 receptor subunit alpha [ Homo sapiens (human) ]

Gene ID: 3587, updated on 2-Nov-2024

Summary

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Official Symbol
IL10RAprovided by HGNC
Official Full Name
interleukin 10 receptor subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:5964
See related
Ensembl:ENSG00000110324 MIM:146933; AllianceGenome:HGNC:5964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1
Summary
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Expression
Broad expression in spleen (RPKM 29.9), bone marrow (RPKM 20.8) and 18 other tissues See more
Orthologs
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Genomic context

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See IL10RA in Genome Data Viewer
Location:
11q23.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (117986394..118003037)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118002773..118019416)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (117857109..117873752)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FXYD6-FXYD2 readthrough Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:117712427-117713626 Neighboring gene FXYD6 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117726457-117726957 Neighboring gene FXYD domain containing ion transport regulator 6 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:117738498-117739697 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:117740007-117740526 Neighboring gene Sharpr-MPRA regulatory region 1172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117778029-117778529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117784655-117785647 Neighboring gene transmembrane serine protease 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5577 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:117802800-117803339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117803340-117803878 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19102 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:117843533-117843947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3941 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5580 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117869597-117870098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117881450-117881950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5581 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19207 Neighboring gene small integral membrane protein 35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117935307-117935808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117947648-117948243 Neighboring gene RNA, 7SL, cytoplasmic 828, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13014 Neighboring gene uncharacterized LOC105369517 Neighboring gene transmembrane serine protease 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation. Murugan D, et al. J Clin Immunol, 2014 Apr. PMID 24519095
  2. Association of the IL-10 receptor A536G (S138G) loss-of-function variant with multiple sclerosis in Tunisian patients. Ben Fredj N, et al. APMIS, 2017 May. PMID 28225209
  3. Genetic variant of IL-10RA and susceptibility to rheumatoid arthritis in a Chinese population. Yang XK, et al. Clin Rheumatol, 2017 Apr. PMID 27796662
  4. The IL-10R1 S138G loss-of-function allele and ulcerative colitis. Grundtner P, et al. Genes Immun, 2009 Jan. PMID 18800073
  5. Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements. Lai CF, et al. J Biol Chem, 1996 Jun 14. PMID 8662928

See all (155) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
    Title: Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
  2. Interleukin-10 receptor signaling promotes the maintenance of a PD-1(int) TCF-1(+) CD8(+) T cell population that sustains anti-tumor immunity.
    Title: Interleukin-10 receptor signaling promotes the maintenance of a PD-1(int) TCF-1(+) CD8(+) T cell population that sustains anti-tumor immunity.
  3. IL-10 receptor expression on lymphocytes and monocytes in children with food allergy.
    Title: IL-10 receptor expression on lymphocytes and monocytes in children with food allergy.
  4. Characterization of novel and large fragment deletions in exon 1 of the IL10RA gene in Chinese children with very early onset inflammatory bowel diseases.
    Title: Characterization of novel and large fragment deletions in exon 1 of the IL10RA gene in Chinese children with very early onset inflammatory bowel diseases.
  5. Intestinal dysbiosis in pediatric Crohn's disease patients with IL10RA mutations.
    Title: Intestinal dysbiosis in pediatric Crohn's disease patients with IL10RA mutations.
  6. IL-10 suppresses IFN-gamma-mediated signaling in lung adenocarcinoma.
    Title: IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma.
  7. [Relationship between gene polymorphism at rs2228055 locus in the exon region of interleukin-10 receptor A and susceptibility to food allergy in children].
    Title: [Relationship between gene polymorphism at rs2228055 locus in the exon region of interleukin-10 receptor A and susceptibility to food allergy in children].
  8. Identification of a novel signaling complex containing host chemokine receptor CXCR4, Interleukin-10 receptor, and human cytomegalovirus US27.
    Title: Identification of a novel signaling complex containing host chemokine receptor CXCR4, Interleukin-10 receptor, and human cytomegalovirus US27.
  9. Erythema Nodosum Leprosum Neutrophil Subset Expressing IL-10R1 Transmigrates into Skin Lesions and Responds to IL-10.
    Title: Erythema Nodosum Leprosum Neutrophil Subset Expressing IL-10R1 Transmigrates into Skin Lesions and Responds to IL-10.
  10. Two SNPs, rs3024490 and rs1800871, were found to be significantly different between breast cancer patients and healthy women. These SNPs also increased the risk of breast cancer in co-dominant and dominant models. Another SNP, rs1554286, was significantly associated with an increased risk of breast cancer in the co-dominant model.
    Title: The effect of interleukin 10 polymorphisms on breast cancer susceptibility in Han women in Shaanxi Province.
Submit: New GeneRIF Correction See all GeneRIFs (81)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Inflammatory bowel disease 28
MedGen: C2751053 OMIM: 613148 GeneReviews: Not available
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EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables interleukin-10 binding IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-10 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-10 receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-10-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intestinal epithelial structure maintenance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse organization IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
interleukin-10 receptor subunit alpha
Names
IL-10 receptor subunit alpha
IL-10R subunit 1
IL-10R subunit alpha
IL-10RA
interleukin 10 receptor, alpha
interleukin-10 receptor alpha chain
interleukin-10 receptor subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016275.1 RefSeqGene

    Range
    5001..20093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_151

mRNA and Protein(s)

  1. NM_001558.4 → NP_001549.2  interleukin-10 receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_001549.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the protein-coding transcript.
    Source sequence(s)
    AK291645, AP002962, BC028082, CA307153
    Consensus CDS
    CCDS8388.1
    UniProtKB/Swiss-Prot
    A8K6I0, B0YJ27, Q13651
    UniProtKB/TrEMBL
    H2DF05
    Related
    ENSP00000227752.4, ENST00000227752.8
    Conserved Domains (2) summary
    pfam01108
    Location:21 → 111
    Tissue_fac; Tissue factor
    cl21522
    Location:129 → 227
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. NR_026691.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate exon compared to variant 1. It is not thought to be protein-coding.
    Source sequence(s)
    AK291645, AK301484, AP002962, BC028082, CA307153

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    117986394..118003037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426882.1 → XP_047282838.1  interleukin-10 receptor subunit alpha isoform X1

  2. XM_047426884.1 → XP_047282840.1  interleukin-10 receptor subunit alpha isoform X3

  3. XM_047426883.1 → XP_047282839.1  interleukin-10 receptor subunit alpha isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    118002773..118019416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368667.1 → XP_054224642.1  interleukin-10 receptor subunit alpha isoform X1

  2. XM_054368669.1 → XP_054224644.1  interleukin-10 receptor subunit alpha isoform X3

  3. XM_054368668.1 → XP_054224643.1  interleukin-10 receptor subunit alpha isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13651.2 GenPept UniProtKB/Swiss-Prot:Q13651

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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