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mxa myxovirus (influenza) resistance A [ Danio rerio (zebrafish) ]

Gene ID: 360142, updated on 14-Nov-2024

Summary

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Official Symbol
mxaprovided by ZNC
Official Full Name
myxovirus (influenza) resistance Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030721-5
See related
Ensembl:ENSDARG00000021688 AllianceGenome:ZFIN:ZDB-GENE-030721-5
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Mx; fj23d12; wu:fj23d12; zgc:136725
Summary
Predicted to enable GTPase activity and microtubule binding activity. Acts upstream of or within response to arsenic-containing substance; response to bacterium; and response to virus. Predicted to be active in several cellular components, including cytoplasm; microtubule; and nucleus. Is expressed in several structures, including digestive system; gill; heart; immune system; and muscle. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to several human genes including MX2 (MX dynamin like GTPase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See mxa in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (7562323..7570219, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (6878890..6886786, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene myosin, light polypeptide 3, skeletal muscle Neighboring gene PEST proteolytic signal containing nuclear protein Neighboring gene myxovirus (influenza) resistance B Neighboring gene ephrin-B2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Labeo rohita Mx1 exhibits the critical structural motifs of the family of large GTPases of mammals and is activated by rhabdovirus vaccination and bacterial RNA stimulations. Samanta M, et al. Anim Biotechnol, 2022 Feb. PMID 32367758
  2. The Role of Histo-Blood Group Antigens and Microbiota in Human Norovirus Replication in Zebrafish Larvae. Cuvry A, et al. Microbiol Spectr, 2022 Dec 21. PMID 36314930, Free PMC Article
  3. Cloning and characterization of an Mx gene and its corresponding promoter from the zebrafish, Danio rerio. Altmann SM, et al. Dev Comp Immunol, 2004 Apr. PMID 14698216
  4. Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses. Sullivan C, et al. J Vis Exp, 2017 Jan 20. PMID 28190053, Free PMC Article
  5. Molecular and functional analysis of an interferon gene from the zebrafish, Danio rerio. Altmann SM, et al. J Virol, 2003 Feb. PMID 12525633, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cloning and analysis of an Mx gene and its corresponding promoter
    Title: Cloning and characterization of an Mx gene and its corresponding promoter from the zebrafish, Danio rerio.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC136725

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to arsenic-containing substance IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interferon-induced GTP-binding protein MxA
Names
IFN-inducible antiviral protein MxA
interferon-inducible MxA protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182942.4 → NP_891987.2  interferon-induced GTP-binding protein MxA

    Status: VALIDATED

    Source sequence(s)
    CT998565
    UniProtKB/Swiss-Prot
    Q8JH68
    UniProtKB/TrEMBL
    A0A8M1PAS6, B8JKI3
    Related
    ENSDARP00000094364.3, ENSDART00000103588.5
    Conserved Domains (3) summary
    cd08771
    Location:35 → 307
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:228 → 510
    Dynamin_M; Dynamin central region
    pfam02212
    Location:547 → 632
    GED; Dynamin GTPase effector domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    7562323..7570219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JH68.1 GenPept UniProtKB/Swiss-Prot:Q8JH68

Gene LinkOut

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