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Abce1 ATP binding cassette subfamily E member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361390, updated on 18-Sep-2024

Summary

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Official Symbol
Abce1provided by RGD
Official Full Name
ATP binding cassette subfamily E member 1provided by RGD
Primary source
RGD:1305301
See related
EnsemblRapid:ENSRNOG00000018345 AllianceGenome:RGD:1305301
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Oabp; Rns4i
Summary
Predicted to enable several functions, including ATP binding activity; endoribonuclease inhibitor activity; and ribosomal small subunit binding activity. Predicted to be involved in negative regulation of endoribonuclease activity; ribosomal subunit export from nucleus; and translation. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to human ABCE1 (ATP binding cassette subfamily E member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 254.5), Thymus (RPKM 240.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Abce1 in Genome Data Viewer
Location:
19q11
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (45109880..45134819)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (28205566..28230489)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (31867960..31892863)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene Hedgehog-interacting protein Neighboring gene uncharacterized LOC134483635 Neighboring gene uncharacterized LOC102549584 Neighboring gene anaphase promoting complex subunit 10 Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene OTU deubiquitinase 4 Neighboring gene uncharacterized LOC102549652

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The expression profile of ATP-binding cassette transporter genes in breast carcinoma. Hlaváč V, et al. Pharmacogenomics, 2013 Apr. PMID 23556449
  2. Rustless translation. Hopfner KP. Biol Chem, 2012 Oct. PMID 23091275
  3. The role of ABC transporters in progression and clinical outcome of colorectal cancer. Hlavata I, et al. Mutagenesis, 2012 Mar. PMID 22294766
  4. Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs. Borel F, et al. Hepatology, 2012 Mar. PMID 21932399
  5. [Expression and clinical significance of ABCE1 in human lung adenocarcinoma]. Liu DZ, et al. Zhonghua Zhong Liu Za Zhi, 2008 Apr. PMID 18788636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables CTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables endoribonuclease inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside triphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal small subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of endoribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of endoribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational termination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational termination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-binding cassette sub-family E member 1
Names
ATP-binding cassette, sub-family E (OABP), member 1
ATP-binding cassette, subfamily E (OABP), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108446.1 → NP_001101916.1  ATP-binding cassette sub-family E member 1

    See identical proteins and their annotated locations for NP_001101916.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    A0A8I6GEV9, A6IYH8
    Related
    ENSRNOP00000024753.7, ENSRNOT00000024753.8
    Conserved Domains (1) summary
    COG1245
    Location:4 → 597
    Rli1; Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    45109880..45134819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255407.5 → XP_006255469.1  ATP-binding cassette sub-family E member 1 isoform X1

    See identical proteins and their annotated locations for XP_006255469.1

    UniProtKB/TrEMBL
    A0A8I6GEV9, A6IYH8
    Conserved Domains (1) summary
    COG1245
    Location:4 → 597
    Rli1; Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]

  2. XM_063278120.1 → XP_063134190.1  ATP-binding cassette sub-family E member 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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