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Triobp TRIO and F-actin binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 362956, updated on 17-Aug-2024

Summary

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Official Symbol
Triobpprovided by RGD
Official Full Name
TRIO and F-actin binding proteinprovided by RGD
Primary source
RGD:1308485
See related
EnsemblRapid:ENSRNOG00000059015 AllianceGenome:RGD:1308485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity and ubiquitin protein ligase binding activity. Predicted to act upstream of or within several processes, including auditory receptor cell stereocilium organization; positive regulation of substrate adhesion-dependent cell spreading; and sensory perception of sound. Predicted to be located in cuticular plate; stereocilium base; and stereocilium shaft. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 28. Orthologous to human TRIOBP (TRIO and F-actin binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 65.2), Lung (RPKM 49.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Triobp in Genome Data Viewer
Location:
7q34
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112386371..112452130)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110505916..110569301)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120173892..120237145)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene galectin 1 Neighboring gene nucleolar protein 12 Neighboring gene H1.0 linker histone Neighboring gene glycine C-acetyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization. Seipel K, et al. J Cell Sci, 2001 Jan. PMID 11148140
  2. The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. Yu J, et al. Biochem Biophys Res Commun, 2008 Mar 21. PMID 18194665
  3. Localization and functional consequences of a direct interaction between TRIOBP-1 and hERG proteins in the heart. Jones DK, et al. J Cell Sci, 2018 Mar 22. PMID 29507111, Free PMC Article
  4. Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Kitajiri S, et al. Cell, 2010 May 28. PMID 20510926, Free PMC Article
  5. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within auditory receptor cell stereocilium organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in stereocilium base ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TRIO and F-actin-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395663.1 → NP_001382592.1  TRIO and F-actin-binding protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6AHC8, B5DFF5
    Related
    ENSRNOP00000092060.1, ENSRNOT00000112806.2
    Conserved Domains (2) summary
    cd13275
    Location:56 → 157
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:329 → 627
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_001409036.1 → NP_001395965.1  TRIO and F-actin-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6G2J5
    Related
    ENSRNOP00000078284.1, ENSRNOT00000094572.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    112386371..112452130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079579.2 → XP_038935507.1  TRIO and F-actin-binding protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6G2J5
    Conserved Domains (5) summary
    PHA03247
    Location:629 → 1070
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:24 → 342
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:1635 → 1946
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13275
    Location:1375 → 1476
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam05109
    Location:241 → 763
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  2. XM_017594983.2 → XP_017450472.1  TRIO and F-actin-binding protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6G2J5
    Related
    ENSRNOP00000071930.2, ENSRNOT00000087548.3
    Conserved Domains (5) summary
    PHA03247
    Location:629 → 1070
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:24 → 342
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:1635 → 1946
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13275
    Location:1375 → 1476
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam05109
    Location:241 → 763
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  3. XM_039079581.1 → XP_038935509.1  TRIO and F-actin-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6G2J5
    Related
    ENSRNOP00000073745.2, ENSRNOT00000086853.3
    Conserved Domains (5) summary
    PHA03247
    Location:628 → 1069
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:24 → 341
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:1634 → 1945
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13275
    Location:1374 → 1475
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam05109
    Location:240 → 762
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  4. XM_039079582.2 → XP_038935510.1  TRIO and F-actin-binding protein isoform X3

    UniProtKB/TrEMBL
    A0A8I6G2J5
    Conserved Domains (3) summary
    PHA03247
    Location:533 → 903
    PHA03247; large tegument protein UL36; Provisional
    PRK08581
    Location:249 → 521
    PRK08581; amidase domain-containing protein
    cd13275
    Location:1375 → 1476
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

  5. XM_039079583.1 → XP_038935511.1  TRIO and F-actin-binding protein isoform X4

    Conserved Domains (2) summary
    PHA03247
    Location:554 → 903
    PHA03247; large tegument protein UL36; Provisional
    PRK08581
    Location:249 → 521
    PRK08581; amidase domain-containing protein

  6. XM_063263918.1 → XP_063119988.1  TRIO and F-actin-binding protein isoform X5

  7. XM_063263919.1 → XP_063119989.1  TRIO and F-actin-binding protein isoform X6

    UniProtKB/TrEMBL
    A0A8I6AHC8, B5DFF5

  8. XM_063263920.1 → XP_063119990.1  TRIO and F-actin-binding protein isoform X7

    UniProtKB/TrEMBL
    Q5M7V4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013220.2: Suppressed sequence

    Description
    NM_001013220.2: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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