Igfbpl1 insulin-like growth factor binding protein-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Igfbpl1provided by RGD
Official Full Name: insulin-like growth factor binding protein-like 1provided by RGD
Primary source: RGD:1305656
See related: EnsemblRapid:ENSRNOG00000011320 AllianceGenome:RGD:1305656
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable insulin-like growth factor binding activity. Predicted to be involved in cellular response to tumor cell and regulation of signal transduction. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human IGFBPL1 (insulin like growth factor binding protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 18.5), Brain (RPKM 16.9) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (64872056..64887461, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (60076428..60091833, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (61395407..61410812, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables insulin-like growth factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: insulin-like growth factor-binding protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108972.2 → NP_001102442.1 insulin-like growth factor-binding protein-like 1 precursor

See identical proteins and their annotated locations for NP_001102442.1

Status: PROVISIONAL

Source sequence(s)

BC158647

UniProtKB/TrEMBL

A0A8I5ZYQ4, B0BN16, F7F674

Related

ENSRNOP00000015270.3, ENSRNOT00000015270.6

Conserved Domains (4) summary

cd00096
Location:164 → 247

Ig; Immunoglobulin domain

smart00280
Location:106 → 143

KAZAL; Kazal type serine protease inhibitors

pfam07679
Location:147 → 252

I-set; Immunoglobulin I-set domain

pfam00219
Location:52 → 83

IGFBP; Insulin-like growth factor binding protein