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yars1 tyrosyl-tRNA synthetase 1 [ Danio rerio (zebrafish) ]

Gene ID: 368235, updated on 2-Nov-2024

Summary

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Official Symbol
yars1provided by ZNC
Official Full Name
tyrosyl-tRNA synthetase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030425-2
See related
Ensembl:ENSDARG00000035913 AllianceGenome:ZFIN:ZDB-GENE-030425-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
yars; cb204; wu:fk52b08
Summary
Predicted to enable tyrosine-tRNA ligase activity. Acts upstream of or within DNA damage response. Predicted to be located in nucleus. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See yars1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (30884966..30895274)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (31297641..31307961)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene MYCL proto-oncogene, bHLH transcription factor b Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid b Neighboring gene NHS like 3 Neighboring gene syncoilin, intermediate filament protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage. Cao X, et al. Proc Natl Acad Sci U S A, 2017 Jan 24. PMID 28069943, Free PMC Article
  2. Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage. Wei N, et al. Mol Cell, 2014 Oct 23. PMID 25284223, Free PMC Article
  3. Characterization of fibronectin type III domain-containing protein 5 (FNDC5) gene in chickens: Cloning, tissue expression, and regulation of its expression in the muscle by fasting and cold exposure. Li X, et al. Gene, 2015 Oct 10. PMID 26072164
  4. Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. Rawls JF, et al. Proc Natl Acad Sci U S A, 2004 Mar 30. PMID 15070763, Free PMC Article
  5. Systematic expression profiling of neuropathy-related aminoacyl-tRNA synthetases in zebrafish during development. Giong HK, et al. Biochem Biophys Res Commun, 2022 Jan 8. PMID 34872004

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tyrosine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tyrosine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tyrosyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
tyrosine--tRNA ligase, cytoplasmic
Names
tyrRS
tyrosyl--tRNA ligase
tyrosyl-tRNA synthetase, cytoplasmic
NP_958473.1
XP_005159655.1
XP_021323679.1
XP_068071142.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201316.1 → NP_958473.1  tyrosine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_958473.1

    Status: PROVISIONAL

    Source sequence(s)
    AY398430
    UniProtKB/Swiss-Prot
    Q6DFZ7, Q6TGS6
    UniProtKB/TrEMBL
    A0A0R4I9C1, A0A8M9PG97
    Related
    ENSDARP00000052125.2, ENSDART00000052126.4
    Conserved Domains (2) summary
    cl00015
    Location:8 → 336
    nt_trans; nucleotidyl transferase superfamily
    cl26127
    Location:293 → 529
    PRK12267; methionyl-tRNA synthetase; Reviewed

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    30884966..30895274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159598.5 → XP_005159655.1  tyrosine--tRNA ligase, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_005159655.1

    UniProtKB/Swiss-Prot
    Q6DFZ7, Q6TGS6
    UniProtKB/TrEMBL
    A0A0R4I9C1, A0A8M9PG97
    Related
    ENSDARP00000144984.1, ENSDART00000183224.1
    Conserved Domains (2) summary
    cl00015
    Location:8 → 336
    nt_trans; nucleotidyl transferase superfamily
    cl26127
    Location:293 → 529
    PRK12267; methionyl-tRNA synthetase; Reviewed

  2. XM_068215041.1 → XP_068071142.1  tyrosine--tRNA ligase, cytoplasmic isoform X1

  3. XM_021468004.2 → XP_021323679.1  tyrosine--tRNA ligase, cytoplasmic isoform X1

    UniProtKB/Swiss-Prot
    Q6DFZ7, Q6TGS6
    UniProtKB/TrEMBL
    A0A0R4I9C1, A0A8M9PG97
    Conserved Domains (2) summary
    cl00015
    Location:8 → 336
    nt_trans; nucleotidyl transferase superfamily
    cl26127
    Location:293 → 529
    PRK12267; methionyl-tRNA synthetase; Reviewed

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395051.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    181732..192036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TGS6.2 GenPept UniProtKB/Swiss-Prot:Q6TGS6

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