paqr8 progestin and adipoQ receptor family member VIII [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: paqr8provided by ZNC
Official Full Name: progestin and adipoQ receptor family member VIIIprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030728-3
See related: Ensembl:ENSDARG00000088828 AllianceGenome:ZFIN:ZDB-GENE-030728-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mprb; zgc:109768
Summary: Enables steroid binding activity. Acts upstream of or within response to steroid hormone and signal transduction. Located in plasma membrane. Is expressed in several structures, including brain; female organism; gill; gonad; and intestine. Orthologous to human PAQR8 (progestin and adipoQ receptor family member 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (34766183..34768301, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (34863304..34865422, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of mPRalpha and mPRbeta increased as follicles developed; investigators also studied regulation of expression of mPRs by oocyte maturation-inducing hormones (TGF-beta1, activin-A, hCG, or BMP-15).
Title: Regulation of membrane progestin receptors in the zebrafish ovary by gonadotropin, activin, TGF-beta and BMP-15.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear steroid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid binding	IBA Inferred from Biological aspect of Ancestor more info
enables steroid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in response to steroid hormone	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to steroid hormone	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: membrane progestin receptor beta

Names: PR beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.