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stat1b signal transducer and activator of transcription 1b [ Danio rerio (zebrafish) ]

Gene ID: 368481, updated on 2-Nov-2024

Summary

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Official Symbol
stat1bprovided by ZNC
Official Full Name
signal transducer and activator of transcription 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-23
See related
Ensembl:ENSDARG00000076182 AllianceGenome:ZFIN:ZDB-GENE-030616-23
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
STAT; STAT1; zgc:55503; wu:fi49f02; si:dz73o4.3; si:dz87i4.1; si:by51f19.2; si:by134g18.3; si:dz199m19.1; si:dz199m19.2; si:xx-51f19.2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hemopoiesis. Predicted to be part of ISGF3 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in cardiovascular system; eye; intermediate cell mass of mesoderm; kidney; and lateral plate mesoderm. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast cancer (multiple); immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See stat1b in Genome Data Viewer
Location:
chromosome: 9
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (41218893..41247197)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (41417122..41445410)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 75 Neighboring gene uncharacterized LOC137496498 Neighboring gene signal transducer and activator of transcription 4 Neighboring gene signal transducer and activator of transcription 1-alpha/beta-like Neighboring gene signal transducer and activator of transcription 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of the Essential Oil from Pistacia lentiscus Var. chia on the Lateral Line System and the Gene Expression Profile of Zebrafish (Danio rerio). Serifi I, et al. Molecules, 2019 Oct 30. PMID 31671694, Free PMC Article
  2. Behavioural fever is a synergic signal amplifying the innate immune response. Boltaña S, et al. Proc Biol Sci, 2013 Sep 7. PMID 23843398, Free PMC Article
  3. Characterization of a mutant samhd1 zebrafish model implicates dysregulation of cholesterol biosynthesis in Aicardi-Goutières syndrome. Withers SE, et al. Front Immunol, 2023. PMID 36949945, Free PMC Article
  4. Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos. Hu H, et al. Toxicol Res (Camb), 2016 Mar 1. PMID 30090375, Free PMC Article
  5. Protein Nanoparticles Made of Recombinant Viral Antigens: A Promising Biomaterial for Oral Delivery of Fish Prophylactics. Thwaite R, et al. Front Immunol, 2018. PMID 30072996, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelium development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ISGF3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
signal transducer and activator of transcription 1b
Names
signal transducer and activator of transcription 1, 91kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200091.2 → NP_956385.2  signal transducer and activator of transcription 1b

    See identical proteins and their annotated locations for NP_956385.2

    Status: VALIDATED

    Source sequence(s)
    BX649377
    UniProtKB/TrEMBL
    A0A8N7V0P4, B0S789
    Related
    ENSDARP00000000280.9, ENSDART00000000280.11
    Conserved Domains (4) summary
    cd16845
    Location:320 → 477
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cl28921
    Location:138 → 316
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam02865
    Location:2 → 119
    STAT_int; STAT protein, protein interaction domain
    cl15255
    Location:559 → 697
    SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    41218893..41247197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167878.5 → XP_005167935.1  signal transducer and activator of transcription 1b isoform X1

    See identical proteins and their annotated locations for XP_005167935.1

    UniProtKB/TrEMBL
    A0A8N7V0P4, B0S789
    Related
    ENSDARP00000115509.1, ENSDART00000145674.3
    Conserved Domains (4) summary
    cd16845
    Location:320 → 477
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cl28921
    Location:138 → 316
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam02865
    Location:2 → 119
    STAT_int; STAT protein, protein interaction domain
    cl15255
    Location:559 → 697
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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