ivd isovaleryl-CoA dehydrogenase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ivdprovided by ZNC
Official Full Name: isovaleryl-CoA dehydrogenaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-262
See related: Ensembl:ENSDARG00000042853 AllianceGenome:ZFIN:ZDB-GENE-030616-262
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb425; wu:fb34d07; si:dz181p14.1
Summary: Predicted to enable 3-methylbutanoyl-CoA dehydrogenase activity. Predicted to be involved in L-leucine catabolic process. Predicted to be active in mitochondrion. Is expressed in alar plate midbrain region; digestive system; immature eye; musculature system; and optic tectum. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and isovaleric acidemia. Orthologous to human IVD (isovaleryl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (31346560..31360914, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (31329597..31343951, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI436903 (e-PCR)
- UniSTS:206614

fk97b10.x1 (e-PCR)
- UniSTS:201809

fb34d07 (e-PCR)
- UniSTS:187090

fb34d07.x1 (e-PCR)
- UniSTS:190436

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 3-methylbutanoyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-methylbutanoyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables short-chain fatty acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-leucine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: isovaleryl-CoA dehydrogenase, mitochondrial

Names: Coenzyme A; isovaleryl Coenzyme A dehydrogenase

NP_958899.1

EC 1.3.8.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201491.1 → NP_958899.1 isovaleryl-CoA dehydrogenase, mitochondrial

See identical proteins and their annotated locations for NP_958899.1

Status: PROVISIONAL

Source sequence(s)

BC045426

UniProtKB/TrEMBL

Q7ZTH9

Related

ENSDARP00000062893.3, ENSDART00000062894.5

Conserved Domains (2) summary

cd01156
Location:38 → 415

IVD; Isovaleryl-CoA dehydrogenase

PLN02519
Location:39 → 411

PLN02519; isovaleryl-CoA dehydrogenase