g2e3 G2/M-phase specific E3 ubiquitin protein ligase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: g2e3provided by ZNC
Official Full Name: G2/M-phase specific E3 ubiquitin protein ligaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-400
See related: Ensembl:ENSDARG00000001313 AllianceGenome:ZFIN:ZDB-GENE-030616-400
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb726; wu:fe02a06; wu:fe24c12; si:dz234g15.1; si:busm1-234g15.1
Summary: Predicted to enable metal ion binding activity and ubiquitin-protein transferase activity. Predicted to be active in nucleus. Is expressed in central nervous system; head; pectoral fin musculature; and proliferative region. Orthologous to human G2E3 (G2/M-phase specific E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (28798727..28811667, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (28781766..28794637, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW165126 (e-PCR)
- UniSTS:205877

fe24c12.x1 (e-PCR)
- UniSTS:196310

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G2/M phase-specific E3 ubiquitin-protein ligase

Names: G2/M-phase specific E3 ubiquitin ligase

NP_001003822.1

EC 2.3.2.26

XP_021322796.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003822.1 → NP_001003822.1 G2/M phase-specific E3 ubiquitin-protein ligase

See identical proteins and their annotated locations for NP_001003822.1

Status: PROVISIONAL

Source sequence(s)

AL596026

UniProtKB/TrEMBL

F6P7Y7, Q78AN7, Q8AW58

Related

ENSDARP00000001315.7, ENSDART00000001444.8

Conserved Domains (3) summary

cd15496
Location:237 → 290

PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)

cd15669
Location:20 → 133

ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)

cl00077
Location:433 → 695

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

28798727..28811667 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467121.2 → XP_021322796.1 G2/M phase-specific E3 ubiquitin-protein ligase isoform X1

UniProtKB/TrEMBL

A0A8M9PKK8

Conserved Domains (3) summary

cd15496
Location:185 → 238

PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)

cl22851
Location:1 → 81

PHD_SF; PHD finger superfamily

cl27008
Location:381 → 643

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...