rrm2b ribonucleotide reductase M2 b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rrm2bprovided by ZNC
Official Full Name: ribonucleotide reductase M2 bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-614
See related: Ensembl:ENSDARG00000033367 AllianceGenome:ZFIN:ZDB-GENE-030616-614
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rrm2; fb72h01; fb93b05; wu:fb72h01; wu:fb93b05; si:zc215i13.5
Summary: Predicted to enable ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Acts upstream of or within DNA damage response and mitochondrial genome maintenance. Located in cytoplasm. Is expressed in several structures, including brain; eye; liver; otic vesicle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (32916345..32928470, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (33331011..33341350, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

functions of p53R2 in zebrafish are closely associated with its activity in DNA repair and synthesis.
Title: Molecular analysis and functions of p53R2 in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fb72h01 (e-PCR)
- UniSTS:187423

fb93b05.x1 (e-PCR)
- UniSTS:191781

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in deoxyribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within deoxyribonucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial genome maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribonucleoside-diphosphate reductase subunit M2 B

NP_001007164.1

EC 1.17.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007163.2 → NP_001007164.1 ribonucleoside-diphosphate reductase subunit M2 B

Status: PROVISIONAL

Source sequence(s)

AL807244

UniProtKB/TrEMBL

A0A8M1N311, Q7ZYW0

Related

ENSDARP00000113482.1, ENSDART00000141404.2

Conserved Domains (1) summary

cl00264
Location:30 → 349

Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins