tuba1b tubulin, alpha 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tuba1bprovided by ZNC
Official Full Name: tubulin, alpha 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030822-1
See related: Ensembl:ENSDARG00000045367 AllianceGenome:ZFIN:ZDB-GENE-030822-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb944; tuba1; fb22g06; wu:fb22g06
Summary: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within microtubule-based process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in several structures, including ectoderm; integument; nervous system; neural tube; and pleuroperitoneal region. Orthologous to several human genes including TUBA1C (tubulin alpha 1c). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 23

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (35713557..35716521)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (35614754..35617718)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that tuba1a-expressing progenitors contribute to multiple cell lineages during development and that tuba1a-expressing Muller glia are retinal progenitors in the adult.
Title: Conditional gene expression and lineage tracing of tuba1a expressing cells during zebrafish development and retina regeneration.
These results suggest tuba1a expression is necessary for CNS development and regeneration and that KLF6a and 7a mediate their effects, at least in part, via transcriptional control of tuba1a promoter activity.
Title: Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish.
Wild-type 1.696 kb & mutant promoters w/o E-box &/or HD sequences had similar activity in developing retina. In mature retina, mutant promoter activity was less. E-box & HD sequences were needed during optic nerve regeneration, but not for retinal injury.
Title: An element in the alpha1-tubulin promoter is necessary for retinal expression during optic nerve regeneration but not after eye injury in the adult zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

kalpha1 (e-PCR)
- UniSTS:205590

fb22g06.x1 (e-PCR)
- UniSTS:203069

D22S981E (e-PCR)
- UniSTS:91370

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tubulin alpha-1B chain

Names: tubulin, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194388.2 → NP_919369.2 tubulin alpha-1B chain

Status: VALIDATED

Source sequence(s)

BX465853

UniProtKB/TrEMBL

A0A0R4IG84, A0A8M1P8U4, B8A516

Related

ENSDARP00000105094.2, ENSDART00000123518.4

Conserved Domains (1) summary

PTZ00335
Location:1 → 448

PTZ00335; tubulin alpha chain; Provisional