hspa9 heat shock protein 9 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hspa9provided by ZNC
Official Full Name: heat shock protein 9provided by ZNC
Primary source: ZFIN:ZDB-GENE-030828-12
See related: Ensembl:ENSDARG00000003035 AllianceGenome:ZFIN:ZDB-GENE-030828-12
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: crs; cb740; hspa9b; wu:fc14d08; wu:fc27c10; wu:fc38a06
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Acts upstream of or within fin regeneration and hemopoiesis. Predicted to be active in mitochondrion. Is expressed in several structures, including digestive system; eye; midbrain; musculature system; and segmental plate. Human ortholog(s) of this gene implicated in Parkinson's disease and autosomal dominant sideroblastic anemia 4. Orthologous to human HSPA9 (heat shock protein family A (Hsp70) member 9). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (12142929..12167631)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (11836915..11861617)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identify an essential role for Hspa9b in hematopoiesis and implicate both loss of HSPA9B specifically and mitochondrial dysfunction generally in the pathogenesis of the MDS
Title: Loss of Hspa9b in zebrafish recapitulates the ineffective hematopoiesis of the myelodysplastic syndrome.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fd25f04.y1 (e-PCR)
- UniSTS:195371

fc27c10.x1 (e-PCR)
- UniSTS:193353

fc14d08.x1 (e-PCR)
- UniSTS:187763

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	NAS Non-traceable Author Statement more info	PubMed
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	NAS Non-traceable Author Statement more info	PubMed
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	NAS Non-traceable Author Statement more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: stress-70 protein, mitochondrial

Names: crimsonless; heat shock protein 9B; mortalin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201326.2 → NP_958483.2 stress-70 protein, mitochondrial

See identical proteins and their annotated locations for NP_958483.2

Status: PROVISIONAL

Source sequence(s)

BC083504

UniProtKB/TrEMBL

Q5XJ12

Related

ENSDARP00000003744.8, ENSDART00000012438.10

Conserved Domains (2) summary

cd11733
Location:55 → 431

HSPA9-like_NBD; Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins

PRK00290
Location:56 → 659

dnaK; molecular chaperone DnaK; Provisional