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cflara CASP8 and FADD-like apoptosis regulator a [ Danio rerio (zebrafish) ]

Gene ID: 373114, updated on 4-Jan-2025

Summary

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Official Symbol
cflaraprovided by ZNC
Official Full Name
CASP8 and FADD-like apoptosis regulator aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030826-3
See related
Ensembl:ENSDARG00000055966 AllianceGenome:ZFIN:ZDB-GENE-030826-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
FLIP; cflar; Clarp1
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to act upstream of or within proteolysis and regulation of apoptotic process. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See cflara in Genome Data Viewer
Location:
chromosome: 11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (30331809..30341431, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (30085775..30094247, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide B7 Neighboring gene UDP glucuronosyltransferase 1 family, pseudogene B6 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide B5 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide B4 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide B3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide B2 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide B1 Neighboring gene transmembrane protein 169a Neighboring gene peroxisomal trans-2-enoyl-CoA reductase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. Inohara N, et al. Proc Natl Acad Sci U S A, 1997 Sep 30. PMID 9380701, Free PMC Article
  2. Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Santoro MM, et al. Nat Genet, 2007 Nov. PMID 17934460
  3. Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change. Sakamaki K, et al. Biochem Biophys Rep, 2015 Sep. PMID 29124180, Free PMC Article
  4. Repression of Puma by scratch2 is required for neuronal survival during embryonic development. Rodríguez-Aznar E, et al. Cell Death Differ, 2011 Jul. PMID 21252910, Free PMC Article
  5. The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2. Essers PB, et al. Oncogene, 2015 Feb 5. PMID 24469044

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CASP8 and FADD-like apoptosis regulator a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313772.1 → NP_001300701.1  CASP8 and FADD-like apoptosis regulator a

    Status: VALIDATED

    Source sequence(s)
    BX323548, EH552705, EH554609, EH575723
    UniProtKB/TrEMBL
    A0A8M1P2J9, F1R706
    Related
    ENSDARP00000072840.2, ENSDART00000078378.5
    Conserved Domains (3) summary
    cd08340
    Location:100 → 180
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    pfam01335
    Location:8 → 87
    DED; Death effector domain
    cl00042
    Location:241 → 461
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    30331809..30341431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479557.2 → XP_021335232.1  CASP8 and FADD-like apoptosis regulator a isoform X1

    UniProtKB/TrEMBL
    A0A8M1P2J9, F1R706
    Conserved Domains (3) summary
    cd08340
    Location:100 → 180
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    pfam01335
    Location:8 → 87
    DED; Death effector domain
    cl00042
    Location:241 → 461
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
Nucleotide Protein Strain
Heading Accession and Version

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