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slc2a8 solute carrier family 2 member 8 [ Danio rerio (zebrafish) ]

Gene ID: 373140, updated on 2-Nov-2024

Summary

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Official Symbol
slc2a8provided by ZNC
Official Full Name
solute carrier family 2 member 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-030829-25
See related
Ensembl:ENSDARG00000104278 AllianceGenome:ZFIN:ZDB-GENE-030829-25
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
slc2a8l; sb:cb753; sb:cb808; zgc:56364
Summary
Predicted to enable D-glucose transmembrane transporter activity. Predicted to be involved in D-glucose transmembrane transport. Predicted to act upstream of or within transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including gill; muscle; nervous system; pericardial region; and pleuroperitoneal region. Orthologous to human SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See slc2a8 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (65970235..65986604)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (65291120..65307489)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ADAMTS-like 2 Neighboring gene tetratricopeptide repeat protein 16 Neighboring gene myomaker, myoblast fusion factor Neighboring gene lipocalin 15 Neighboring gene uncharacterized LOC137495658

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish. Michel M, et al. Proc Natl Acad Sci U S A, 2016 Mar 15. PMID 26903647, Free PMC Article
  2. Specific expression and regulation of glucose transporters in zebrafish ionocytes. Tseng YC, et al. Am J Physiol Regul Integr Comp Physiol, 2009 Aug. PMID 19458281
  3. Ghrelin affects carbohydrate-glycogen metabolism via insulin inhibition and glucagon stimulation in the zebrafish (Danio rerio) brain. Cruz SA, et al. Comp Biochem Physiol A Mol Integr Physiol, 2010 Jun. PMID 20138234
  4. Loss of glyoxalase 2 alters the glucose metabolism in zebrafish. Tabler CT, et al. Redox Biol, 2023 Feb. PMID 36535130, Free PMC Article
  5. Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish. Xi L, et al. Front Nutr, 2023. PMID 37305084, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 8
Names
solute carrier family 2 (facilitated glucose transporter), member 8
zglut8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212798.1 → NP_997963.1  solute carrier family 2, facilitated glucose transporter member 8

    See identical proteins and their annotated locations for NP_997963.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049409
    UniProtKB/TrEMBL
    Q7ZWH3
    Related
    ENSDARP00000133291.1, ENSDART00000166432.2
    Conserved Domains (2) summary
    cd06174
    Location:40 → 477
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:39 → 492
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    65970235..65986604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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