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ZNF773 zinc finger protein 773 [ Homo sapiens (human) ]

Gene ID: 374928, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF773provided by HGNC
Official Full Name
zinc finger protein 773provided by HGNC
Primary source
HGNC:HGNC:30487
See related
Ensembl:ENSG00000152439 AllianceGenome:HGNC:30487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF419B
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 2.6), ovary (RPKM 2.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF773 in Genome Data Viewer
Location:
19q13.43
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57499938..57518437)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60596886..60615371)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58011306..58029805)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:57988249-57989448 Neighboring gene zinc finger protein 772 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:57998906-57999406 Neighboring gene zinc finger protein 419 Neighboring gene zinc finger protein 549 Neighboring gene zinc finger protein 550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58070497-58071361 Neighboring gene uncharacterized LOC124904781 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:58071339-58072538

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
  2. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
  3. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
  4. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
  5. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC4728, FLJ00301

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 773
Names
zinc finger protein 419B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304334.2 → NP_001291263.1  zinc finger protein 773 isoform b

    See identical proteins and their annotated locations for NP_001291263.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC003005, AK057209
    Consensus CDS
    CCDS77368.1
    UniProtKB/Swiss-Prot
    Q6PK81
    Related
    ENSP00000469416.1, ENST00000598770.5
    Conserved Domains (5) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:208 → 437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:192 → 212
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:372 → 396
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001304335.3 → NP_001291264.1  zinc finger protein 773 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' structure, and uses an alternate in-frame splice site in the central coding region, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) is shorter, and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC003005, AC003682, DA650616
    UniProtKB/TrEMBL
    M0QX16
    Related
    ENSP00000468846.1, ENST00000599847.5
    Conserved Domains (2) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    pfam01352
    Location:14 → 53
    KRAB; KRAB box

  3. NM_001304336.2 → NP_001291265.1  zinc finger protein 773 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR, and uses two alternate splice site in the coding region, one of which results in a frameshift compared to variant 1. The encoded isoform (d) is shorter, and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC003005
    UniProtKB/TrEMBL
    E5RIA3
    Conserved Domains (1) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box

  4. NM_001304337.3 → NP_001291266.1  zinc finger protein 773 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' structure, and uses an alternate in-frame splice site in the central coding region, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e) is shorter, and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC003005, AC003682
    Consensus CDS
    CCDS77369.1
    UniProtKB/TrEMBL
    M0QX16, M0QYZ8
    Related
    ENSP00000470189.1, ENST00000593916.5
    Conserved Domains (1) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box

  5. NM_198542.3 → NP_940944.1  zinc finger protein 773 isoform a

    See identical proteins and their annotated locations for NP_940944.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC003005, BC005167
    Consensus CDS
    CCDS33134.1
    UniProtKB/Swiss-Prot
    Q6PK81, Q96DL8
    Related
    ENSP00000282292.3, ENST00000282292.9
    Conserved Domains (5) summary
    smart00349
    Location:15 → 75
    KRAB; krueppel associated box
    COG5048
    Location:209 → 438
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:193 → 213
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 54
    KRAB; KRAB box
    pfam13465
    Location:373 → 397
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_130705.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC003005, BX365407, BX382674
    Related
    ENST00000597061.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57499938..57518437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007066799.1 RNA Sequence

  2. XR_007066800.1 RNA Sequence

  3. XR_007066801.1 RNA Sequence

  4. XR_007066802.1 RNA Sequence

  5. XR_007066803.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60596886..60615371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008485141.1 RNA Sequence

  2. XR_008485142.1 RNA Sequence

  3. XR_008485143.1 RNA Sequence

  4. XR_008485144.1 RNA Sequence

  5. XR_008485145.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PK81.1 GenPept UniProtKB/Swiss-Prot:Q6PK81

Gene LinkOut

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