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POLY polyprotein;protein F [ Hepatitis C virus (isolate H77) ]

Gene ID: 37619432, updated on 18-Aug-2023

Summary

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Gene symbol
POLY
Gene description
polyprotein;protein F
Locus tag
D1Q49_gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Hepatitis C virus (isolate H77) (strain: H77)
Lineage
Viruses; Riboviria; Flaviviridae; Hepacivirus
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Genomic context

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Location:
clone: pCV-H77C
Sequence:
NC_038882.1 (342..9377)

NC_038882.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_038882.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization. Pierce BG, et al. J Virol, 2020 Oct 27. PMID 32878891, Free PMC Article
  2. Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee. Yanagi M, et al. Proc Natl Acad Sci U S A, 1997 Aug 5. PMID 9238047, Free PMC Article
  3. PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly. Nguyen LP, et al. J Virol, 2020 Feb 14. PMID 31801866, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization.
    Title: Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization.
  2. PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly.
    Title: PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly.
Submit: New GeneRIF Correction

General protein information

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Preferred Names
polyprotein;protein F
Names
core protein
E1 protein
E2 protein
p7 protein
NS2 protein
NS3 protease/helicase
NS4A protein
NS4B protein
NS5A protein
NS5B RNA-dependent RNA polymerase
YP_009590640.1
  • Potential -2/+1 frameshift protein F; position predicted based on homology to protein F in HCV1 RefSeq NC_004102.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_038882.1 Reference assembly

    Range
    342..9377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009506357.1 polyprotein [Hepatitis C virus (isolate H77)]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q9ELS8
    Conserved Domains (15) summary
    pfam01001
    Location:1728 → 1921
    HCV_NS4b; Hepatitis C virus non-structural protein NS4b
    pfam01539
    Location:193 → 382
    HCV_env; Hepatitis C virus envelope glycoprotein E1
    pfam01560
    Location:386 → 729
    HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
    pfam02907
    Location:1056 → 1204
    Peptidase_S29; Hepatitis C virus NS3 protease
    pfam01543
    Location:2 → 115
    HCV_capsid; Hepatitis C virus capsid protein
    pfam08301
    Location:2068 → 2168
    HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
    pfam01538
    Location:811 → 1005
    HCV_NS2; Hepatitis C virus non-structural protein NS2
    smart00487
    Location:1228 → 1355
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:1378 → 1455
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam01542
    Location:116 → 190
    HCV_core; Hepatitis C virus core protein
    pfam12941
    Location:2179 → 2420
    HCV_NS5a_C; HCV NS5a protein C-terminal region
    pfam00998
    Location:2423 → 2934
    RdRP_3; Viral RNA dependent RNA polymerase
    pfam01006
    Location:1658 → 1711
    HCV_NS4a; Hepatitis C virus non-structural protein NS4a
    pfam01506
    Location:1974 → 1996
    HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
    pfam08300
    Location:2006 → 2067
    HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain

  2. YP_009709861.1 core protein

    UniProtKB/TrEMBL
    A0A075C2Z9, A0A075C392, A0A075C3A1, A0A075C3F8, A0A075C549, A0A075C551, A0A075C673, A0A077CW64, A0A077CW68, A0A077CW83, A0A077CW92, A0A077CW98, A0A077CWX7, A0A077CWY1, A0A077CWY6, A0A077CWZ4, A0A077CX03, A0A077CX08, A0A077CX16, A0A077CYR9, A0A077CYS6, A0A077CYU1, A0A077CYU8, A0A077CYW6, A0A077D120, A0A077D125, A0A077D131, A0A077D140, A0A077D156, A0A077D1H5, A0A077D1I0, A0A077D1I6, A0A077D1J1, A0A077D1J4, A0A077D1K6, A0A0A0YPR1, A0A221C814, A0A2Z4SVT1, A0A2Z4SVU0, A0A2Z4SVV0, A0A2Z4SVX4, A0A2Z4SVY6, A0A2Z4SVY8, A0A2Z4SW42, A0A2Z4SW47, A0A2Z4SW52, A0A2Z4SW53, A0A2Z4SW62, A0A2Z4SW65, A0A2Z4SW72, A0A2Z4SW76, A0A2Z4SW83, A0A2Z4SW87, A0A2Z4SW92, A0A2Z4SWA8, A0A2Z4SWB3, A0A2Z4SWD6, A0A2Z4SWE3, A0A2Z4SWE7, A0A2Z4SWF3, A0A2Z4SWG0, A0A2Z4SWG2, A0A2Z4SWG7, A0A2Z4SWG9, A0A2Z4SWH1, A0A2Z4SWH7, A0A2Z4SWI0, A0A2Z4SWI2, A0A2Z4SWI6, A0A2Z4SWI7, A0A2Z4SWI8, A0A2Z4SWJ5, A0A2Z4SWJ6, A0A2Z4SWJ7, A0A2Z4SWK2, A0A2Z4SWK4, A0A2Z4SWM2, A0A2Z4SWM6, A0A2Z4SWP3, A0A2Z4SWQ3, A0A2Z4SWR0, A0A2Z4SWS0, A0A2Z4SWS6, A0A2Z4SWT0, A0A2Z4SWT5, A0A2Z4SWU6, A0A2Z4SWV5, A0A2Z4SWX3, A0A2Z4SX06, A0A2Z4SX13, A0A2Z4SX22, A0A2Z4SX30, A0A2Z4SX88, A0A2Z4SX94, A0A2Z4SXC4, A0A2Z4SXE4, A0A2Z4SXG6, A0A2Z4SXH4, A0A2Z4SXI2, A0A2Z4SXI3, A0A2Z4SXJ3, A0A2Z4SXK8, A0A2Z4SXM1, A0A2Z4SXN0, A0A2Z4SXN5, A0A2Z4SXQ7, A0A2Z4SXR6, A0A2Z4SXS5, A0A2Z4SXT4, A0A2Z4SXU4, A0A2Z4SXV4, A0A2Z4SXW1, A0A2Z4SXW4, A0A2Z4SXW7, A0A2Z4SXY3, A0A2Z4SXZ8, A0A2Z4SY03, A0A2Z4SY17, A0A2Z4SY19, A0A2Z4SY33, A0A2Z4SY49, A0A2Z4SY52, A0A2Z4SY69, A0A2Z4SY73, A0A2Z4SY88, A0A2Z4SYB9, A0A2Z4SYD0, A0A2Z4T039, A0A2Z4T0D6, A0A2Z4T0G1, A0A2Z4T0I4, A0A2Z4T0J9, A0A2Z4T0L7, A0A2Z4T0M3, A0A2Z4T0P9, A0A2Z4T0S9, A0A2Z4T176, A0A2Z4T1E9, A0A2Z4T1F4, A0A2Z4T1H8, A0A2Z4T1K0, A0A2Z4T1L6, A0A2Z4T1M4, A0A2Z4T1N3, A0A2Z4T1R4, A0A2Z4T1S5, A0A2Z4T1T3, A0A2Z4T233, A0A2Z4T260, A0A2Z4T2B0, A0A2Z4T2B9, A0A2Z4T2H1, A0A2Z4T2K2, A0A2Z4T2N1, A0A2Z4T2N9, A0A2Z4T2Q9, A0A650G1H4, A0A650G1T5, A0A650G1W3, A0A654JSZ4, B8Y460, C8CP42, D0UVL8, D0UVL9, D0UVM0, D0UVM1, D2E5C6, D2E5D5, D2E5D6, D2E5D7, D2E5D8, D2E5D9, D2E5E0, D3HU87, D3HU88, D3HU89, D3HU90, D3HU91, D3HU92, D3HU93, D3HU94, D3HU95, D3HU98, D3HU99, D3HUA0, D3HUA1, D3HUA2, D3HUA3, D3HUA5, D3HUA6, D3HUA7, D3HUA8, D3HUA9, D3HUB0, D3HUB6, D3HUB9, D3HUC0, D3HUC1, D3HUC2, D7R6Q6, D7R6Q7, D7R6Q9, D7R6R0, D7R6R4, D7R6R5, E2ICK2, E6Z821, G3FEN7, G3FEN8, L7Z1C8, L7Z1D2, L7Z1F6, L7Z1G2, L7Z5V0, L7Z5V3, L7Z5X5, L7Z6V5, L7Z6Y6, L7Z7D6, L7Z951, Q68113, Q68123, Q68124, Q68139, Q68149, Q6QY91, Q6QY92, Q6QY99, Q6QYA1, Q6QYA2, Q6QYA6, Q6QYA7, Q6QYA8, Q6QYB1, Q6QYB2, Q6QYB4, Q6QYB6, Q6QYB7, Q6QYB8, Q6QYB9, Q6QYC1, Q6QYC2, Q6QYC3, Q6QYE5, Q6QYE6, Q6QYE7, Q6QYE8, Q6QYE9, Q6QYF0, Q6QYF1, Q6QYF2, Q6QYF6, Q6QYF7, Q6QYF9, Q6QYG0, Q6QYG5, Q6QYJ7, Q6QYJ9, Q6QYK0, Q6QYK2, Q6QYK3, Q6QYK6, Q6QYK7, Q6QYK8, Q6QYK9, Q6QYL0, Q6QYL1, Q6QYL2, Q6QYL4, Q6QYL5, Q6QYM0, Q6QYN0, Q6QYQ9, Q6QYR0, Q6QYR1, Q6QYR2, Q6QYR3, Q6QYR4, Q6QYR5, Q6QYR6, Q6QYR7, Q6QYT2, Q6QYT4, Q6QYT5, Q6QYT6, Q6QYT7, Q6QYT8, Q6QYT9, Q6QYU0, Q6QYU1, Q6QYU2, Q6QYU3, Q6QYY8, Q6QYZ1, Q6QZ00, Q6QZ04, Q6QZ15, Q6QZ18, Q6QZ19, Q6QZ20, Q6QZ21, Q6QZ22, Q6QZ25, Q6QZ26, Q6QZ27, Q6QZ28, Q6QZ29, Q6QZ31, Q6QZ32, Q6QZ56, Q6QZ58, Q6QZ60, Q6QZ61, Q6QZ62, Q6QZ63, Q6QZ64, Q6QZ67, Q6QZ80, Q6QZ81, Q6QZ82, Q6QZ83, Q6QZ84, Q6QZ85, Q6QZ87, Q6QZ88, Q6QZ91, Q6QZ99, Q6QZA0, Q6QZA1, Q6QZA2, Q6QZA3, Q6QZA4, Q6QZA5, Q6QZA6, Q6QZA7, Q6QZA9, Q6QZD2, Q6QZD3, Q6QZD8, Q6QZE2, Q6QZE3, Q6QZE5, Q6QZE6, Q6QZE7, Q6QZE8, Q6QZE9, Q6QZF1, Q6QZF2, Q6QZG0, Q6QZG4, Q6QZG5, Q6QZG6, Q6QZG7, Q6QZG8, Q6QZG9, Q6QZH0, Q6QZH1, Q6QZH2, Q6QZH3, Q6UNT8, Q8BES1
    Conserved Domains (2) summary
    pfam01543
    Location:2 → 115
    HCV_capsid; Hepatitis C virus capsid protein
    pfam01542
    Location:116 → 190
    HCV_core; Hepatitis C virus core protein

  3. YP_009709862.1 E1 protein

    UniProtKB/TrEMBL
    B6URW2, B6URW4, B6URW7, B6URW8, B6URX0, B6URX2, B6URX7, B6URX8, B6URY0, B6URY1
    Conserved Domains (1) summary
    pfam01539
    Location:2 → 191
    HCV_env; Hepatitis C virus envelope glycoprotein E1

  4. YP_009709863.1 E2 protein

    Conserved Domains (1) summary
    pfam01560
    Location:3 → 346
    HCV_NS1; Hepatitis C virus non-structural protein E2/NS1

  5. YP_009709864.1 p7 protein

    UniProtKB/TrEMBL
    Q0JXG3, Q5QRE5, Q5QRE6, Q5QRE7, Q5QRE8, Q5QRF3, Q5QRF7, Q5QRF8, Q5QRF9, Q5QRG0, Q5QRG1, Q5QRG3, Q5QRG5, Q5QRG6, Q5QRG7, Q5QRU1
    Conserved Domains (1) summary
    cd20903
    Location:1 → 49
    HCV_p7; Hepatitis C virus p7 protein

  6. YP_009709865.1 NS2 protein

    UniProtKB/TrEMBL
    C9WTV6, G8CQ45, G8CQ46, G8CQ47, G8CQ48
    Conserved Domains (1) summary
    pfam01538
    Location:2 → 196
    HCV_NS2; Hepatitis C virus non-structural protein NS2

  7. YP_009709866.1 NS3 protease/helicase

    UniProtKB/TrEMBL
    A0A0A7HBI9, A1Z092, A1Z094
    Conserved Domains (3) summary
    cl38915
    Location:336 → 457
    DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
    pfam02907
    Location:30 → 178
    Peptidase_S29; Hepatitis C virus NS3 protease
    cl28899
    Location:197 → 340
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  8. YP_009709867.1 NS4A protein

    UniProtKB/TrEMBL
    C9WTY9, C9WTZ4, C9WU13, C9WU32, C9WU38, C9WU40, C9WU43, C9WU50, C9WU54, C9WU62, C9WU67, C9WU74, C9WU75, C9WU76, C9WU93, C9WUA4, C9WUB2, C9WUB9, C9WUC7, C9WUC9, C9WUD5, C9WUD6, C9WUE1, C9WUE4
    Conserved Domains (1) summary
    pfam01006
    Location:1 → 54
    HCV_NS4a; Hepatitis C virus non-structural protein NS4a

  9. YP_009709868.1 NS4B protein

    UniProtKB/TrEMBL
    C9WUH7, C9WUM0
    Conserved Domains (1) summary
    pfam01001
    Location:17 → 210
    HCV_NS4b; Hepatitis C virus non-structural protein NS4b

  10. YP_009709869.1 NS5A protein

    UniProtKB/TrEMBL
    Q14T61, Q9E394
    Conserved Domains (4) summary
    pfam08301
    Location:96 → 196
    HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
    pfam12941
    Location:207 → 448
    HCV_NS5a_C; HCV NS5a protein C-terminal region
    pfam01506
    Location:2 → 24
    HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
    pfam08300
    Location:34 → 95
    HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain

  11. YP_009709870.1 NS5B RNA-dependent RNA polymerase

    UniProtKB/TrEMBL
    A0A2H4YTE1
    Conserved Domains (1) summary
    pfam00998
    Location:3 → 514
    RdRP_3; Viral RNA dependent RNA polymerase

  12. YP_009590640.1 protein F [Hepatitis C virus (isolate H77)]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0C045
    Conserved Domains (1) summary
    pfam01543
    Location:66 → 127
    HCV_capsid; Hepatitis C virus capsid protein
Nucleotide Protein
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