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BMRF2 envelope protein UL43 [ Human gammaherpesvirus 4 (Epstein-Barr virus) ]

Gene ID: 3783719, updated on 20-Nov-2023

Summary

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Gene symbol
BMRF2
Gene description
envelope protein UL43
Locus tag
HHV4_BMRF2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 4 (strain: B95-8, strain: Raji, type: 1, common: Epstein-Barr virus, acronym: EBV, acronym: HHV-4, nat-host: Homo sapiens)
Lineage
Viruses; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
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Genomic context

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Sequence:
NC_007605.1 (68491..69916)

NC_007605.1Genomic Context describing neighboring genes Neighboring gene nuclear antigen EBNA-3B;nuclear antigen EBNA-3C Neighboring gene nuclear antigen EBNA-3A Neighboring gene protein-coding Neighboring gene DNA packaging protein UL33 Neighboring gene nuclear egress membrane protein Neighboring gene protein UL49 Neighboring gene nuclear antigen EBNA-1 Neighboring gene small capsid protein Neighboring gene large tegument protein Neighboring gene tegument protein UL37 Neighboring gene capsid triplex subunit 1 Neighboring gene multifunctional expression regulator Neighboring gene ribonucleotide reductase subunit 1 Neighboring gene ribonucleotide reductase subunit 2 Neighboring gene DNA polymerase processivity subunit Neighboring gene helicase-primase primase subunit Neighboring gene tegument protein UL51

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007605.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EBV BMRF-2 facilitates cell-to-cell spread of virus within polarized oral epithelial cells. Xiao J, et al. Virology, 2009 Jun 5. PMID 19394065, Free PMC Article
  2. Characterization of the Epstein-Barr virus glycoprotein BMRF-2. Xiao J, et al. Virology, 2007 Mar 15. PMID 17081581
  3. Epstein-Barr virus BDLF2-BMRF2 complex affects cellular morphology. Loesing JB, et al. J Gen Virol, 2009 Jun. PMID 19264620
  4. Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV. de Jesus O, et al. J Gen Virol, 2003 Jun. PMID 12771413
  5. The EB virus genome in Daudi Burkitt's lymphoma cells has a deletion similar to that observed in a non-transforming strain (P3HR-1) of the virus. Jones MD, et al. EMBO J, 1984 Apr. PMID 6327290, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutation of the tyrosine- and dileucine-containing basolateral sorting signal, YLLV, in the cytoplasmic domain of BMRF-2 led to the failure of its accumulation in the TGN and its basolateral transport
    Title: EBV BMRF-2 facilitates cell-to-cell spread of virus within polarized oral epithelial cells.
  2. When the two proteins were co-expressed, BDLF2 was transported with BMRF2 to the Golgi apparatus and from there to the plasma membrane, where the proteins co-localized extensively.
    Title: Epstein-Barr virus BDLF2-BMRF2 complex affects cellular morphology.
  3. BMRF-2 is a ligand for beta1, alpha5, alpha3, and alphav integrins and data are consistent with a role for BMRF-2 in viral lytic infection
    Title: Characterization of the Epstein-Barr virus glycoprotein BMRF-2.
Submit: New GeneRIF Correction

General gene information

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regulatory

  • Loc: 68491-68496 regulatory_class = TATA_box
  • Loc: 68544-68549 regulatory_class = TATA_box
  • Loc: 69892-69897 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
envelope protein UL43

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007605.1 Reference assembly

    Range
    68491..69916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_401658.1 envelope protein UL43 [Human gammaherpesvirus 4]

    See identical proteins and their annotated locations for YP_401658.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03192, Q777F8
    UniProtKB/TrEMBL
    A0A0C7T4C1, A0A0C7TQY0, A0A0C7TXQ8, A0A0F6QKE0, A0A191T6U1, A0A2S1MPQ4, A0A2S1MTK5, A0A2S1MUX0, A0A3R5TN54, A0A3R5TQQ4, A0A3R5X1W7, A0A3R5XLK6, A0A451G6G8, A0A4D6TXJ6, G3CKQ4, I1YP13, V5KU08
    Conserved Domains (1) summary
    pfam04633
    Location:10 → 355
    Herpes_BMRF2; Herpesvirus BMRF2 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
1208408C.1

Gene LinkOut

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