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BXLF1 thymidine kinase [ Human gammaherpesvirus 4 (Epstein-Barr virus) ]

Gene ID: 3783741, updated on 20-Nov-2023

Summary

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Gene symbol
BXLF1
Gene description
thymidine kinase
Locus tag
HHV4_BXLF1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 4 (strain: B95-8, strain: Raji, type: 1, common: Epstein-Barr virus, acronym: EBV, acronym: HHV-4, nat-host: Homo sapiens)
Lineage
Viruses; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
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Genomic context

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Sequence:
NC_007605.1 (128608..132846, complement)

NC_007605.1Genomic Context describing neighboring genes Neighboring gene envelope glycoprotein 150 Neighboring gene envelope glycoprotein 48 Neighboring gene capsid triplex subunit 2 Neighboring gene major capsid protein Neighboring gene protein UL87 Neighboring gene tegument protein UL88 Neighboring gene envelope glycoprotein H Neighboring gene nuclear protein UL24 Neighboring gene DNA packaging tegument protein UL25 Neighboring gene protein UL79 Neighboring gene capsid maturation protease Neighboring gene capsid scaffold protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007605.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production. Meng Q, et al. J Virol, 2010 May. PMID 20181711, Free PMC Article
  2. Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV. de Jesus O, et al. J Gen Virol, 2003 Jun. PMID 12771413
  3. The EB virus genome in Daudi Burkitt's lymphoma cells has a deletion similar to that observed in a non-transforming strain (P3HR-1) of the virus. Jones MD, et al. EMBO J, 1984 Apr. PMID 6327290, Free PMC Article
  4. Organization of the Epstein-Barr virus DNA molecule. III. Location of the P3HR-1 deletion junction and characterization of the NotI repeat units that form part of the template for an abundant 12-O-tetradecanoylphorbol-13-acetate-induced mRNA transcript. Jeang KT, et al. J Virol, 1983 Oct. PMID 6310141, Free PMC Article
  5. DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Baer R, et al. Nature, 1984 Jul 19-25. PMID 6087149

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data show that Epstein-Barr virus BGLF4 (protein kinase) but not BXLF1 (thymidine kinase) mediates acyclovir and ganciclovir susceptibilities.
    Title: The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production.
Submit: New GeneRIF Correction

General gene information

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regulatory

  • Loc: c128613-128608 regulatory_class = polyA_signal_sequence
  • Loc: c131021-131016 regulatory_class = TATA_box
  • Loc: c132844-132839 regulatory_class = TATA_box

General protein information

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Preferred Names
thymidine kinase
YP_401701.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007605.1 Reference assembly

    Range
    128608..132846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_401701.1 thymidine kinase [Human gammaherpesvirus 4]

    See identical proteins and their annotated locations for YP_401701.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03177, Q777B9
    UniProtKB/TrEMBL
    A0A0A8IL93, A0A0C7T3Q3, A0A0C7T4H6, A0A0C7T5Q4, A0A0C7TEJ4, A0A0C7TIU3, A0A0C7TTC3, A0A0C7TWW9, A0A0X8W0P0, A0A0X9C5N0, A0A2D1M0I8, A0A2S1MPM8, A0A2S1MT42, A0A2S1MUZ5, A0A2S1N079, A0A2S1N136, A0A2S1N2S7, A0A385J9L0, A0A385JA61, A0A3R5ZHB8, A0A410IP17, A0A4D6TX16, A0A4D6U0X8, K9UTT7
    Conserved Domains (1) summary
    PHA03132
    Location:4 → 607
    PHA03132; thymidine kinase; Provisional
Nucleotide Protein
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