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fbxl3a F-box and leucine-rich repeat protein 3a [ Danio rerio (zebrafish) ]

Gene ID: 378451, updated on 4-Jan-2025

Summary

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Official Symbol
fbxl3aprovided by ZNC
Official Full Name
F-box and leucine-rich repeat protein 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030912-5
See related
Ensembl:ENSDARG00000103505 AllianceGenome:ZFIN:ZDB-GENE-030912-5
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7153024; zgc:103721
Summary
Acts upstream of or within circadian sleep/wake cycle. Predicted to be active in cytosol and nucleus. Orthologous to human FBXL3 (F-box and leucine rich repeat protein 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See fbxl3a in Genome Data Viewer
Location:
chromosome: 9
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (16863650..16877582, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (16859482..16870077, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene radial spoke head component 1 Neighboring gene uncharacterized LOC137490345 Neighboring gene CLN5 intracellular trafficking protein Neighboring gene MYC binding protein 2 Neighboring gene uncharacterized LOC137496462

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System. Confino S, et al. Int J Mol Sci, 2022 Feb 21. PMID 35216494, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System.
    Title: A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within circadian sleep/wake cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in entrainment of circadian clock by photoperiod IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 3
Names
F-box/LRR-repeat protein 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005773.3 → NP_001005773.3  F-box/LRR-repeat protein 3

    Status: VALIDATED

    Source sequence(s)
    CT573248
    UniProtKB/TrEMBL
    A8KBX2, Q5XJ37, Q7T162
    Related
    ENSDARP00000136592.1, ENSDART00000161105.2
    Conserved Domains (2) summary
    sd00034
    Location:178 → 203
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:40 → 81
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    16863650..16877582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009304564.4 → XP_009302839.1  F-box/LRR-repeat protein 3 isoform X1

    UniProtKB/TrEMBL
    A8KBX2, Q5XJ37, Q7T162
    Related
    ENSDARP00000133135.1, ENSDART00000160869.2
    Conserved Domains (2) summary
    sd00034
    Location:178 → 203
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:40 → 81
    F-box-like; F-box-like

  2. XM_068223337.1 → XP_068079438.1  F-box/LRR-repeat protein 3 isoform X1

    UniProtKB/TrEMBL
    A8KBX2, Q5XJ37, Q7T162

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394745.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    40329..54261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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