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rdh10b retinol dehydrogenase 10b [ Danio rerio (zebrafish) ]

Gene ID: 378722, updated on 22-Dec-2024

Summary

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Official Symbol
rdh10bprovided by ZNC
Official Full Name
retinol dehydrogenase 10bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030909-7
See related
Ensembl:ENSDARG00000012369 AllianceGenome:ZFIN:ZDB-GENE-030909-7
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb804; rdh10
Summary
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in retinol metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in lipid droplet. Is expressed in several structures, including axis; notochord; pleuroperitoneal region; tail bud; and yolk syncytial layer. Orthologous to human RDH10 (retinol dehydrogenase 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See rdh10b in Genome Data Viewer
Location:
chromosome: 2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (30182669..30186307)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (30199136..30202774)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily B member 2a Neighboring gene small nucleolar SNORD12/SNORD106 Neighboring gene ribosomal protein L7 Neighboring gene ubiquitin conjugating enzyme E2 Wa Neighboring gene transfer RNA asparagine (anticodon GUU)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development. Nadauld LD, et al. Proc Natl Acad Sci U S A, 2006 Sep 5. PMID 16938888, Free PMC Article
  2. Depletion of retinoic acid receptors initiates a novel positive feedback mechanism that promotes teratogenic increases in retinoic acid. D'Aniello E, et al. PLoS Genet, 2013. PMID 23990796, Free PMC Article
  3. TETs Regulate Proepicardial Cell Migration through Extracellular Matrix Organization during Zebrafish Cardiogenesis. Lan Y, et al. Cell Rep, 2019 Jan 15. PMID 30650362, Free PMC Article
  4. Shedding new light on early sex determination in zebrafish. King AC, et al. Arch Toxicol, 2020 Dec. PMID 32975586, Free PMC Article
  5. Retinoic acid signaling controls the formation, proliferation and survival of the blastema during adult zebrafish fin regeneration. Blum N, et al. Development, 2012 Jan. PMID 22096078

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
retinol dehydrogenase 10-B
Names
retinol dehydrogenase 10
NP_958488.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201331.1 → NP_958488.1  retinol dehydrogenase 10-B

    See identical proteins and their annotated locations for NP_958488.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054596
    UniProtKB/Swiss-Prot
    B0V2U0, Q7T2D1
    UniProtKB/TrEMBL
    B2GPJ5
    Related
    ENSDARP00000011528.8, ENSDART00000004903.9
    Conserved Domains (2) summary
    cd05339
    Location:38 → 302
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    COG0300
    Location:36 → 309
    DltE; Short-chain dehydrogenase [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    30182669..30186307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7T2D1.2 GenPept UniProtKB/Swiss-Prot:Q7T2D1

Gene LinkOut

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