akt2 v-akt murine thymoma viral oncogene homolog 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: akt2provided by ZNC
Official Full Name: v-akt murine thymoma viral oncogene homolog 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-031007-5
See related: Ensembl:ENSDARG00000011219 AllianceGenome:ZFIN:ZDB-GENE-031007-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb945
Summary: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including bone development; glucose homeostasis; and positive regulation of D-glucose import. Is expressed in several structures, including brain; gill; heart; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); high grade glioma; and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (40711191..40753541, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (40720999..40763349, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis.
Title: Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis.
Study reports that Appl1 regulates the activity of Akt and, importantly, its downstream signaling specificity from an endosomal compartment, with profound implications for development.
Title: The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development.
EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.
Title: Overexpression of endothelin 1 triggers hepatocarcinogenesis in zebrafish and promotes cell proliferation and migration through the AKT pathway.
akt2 has a role in an integrative pathway directly linking glucose, Glut1 expression, and activation of apoptosis
Title: Akt2 modulates glucose availability and downstream apoptotic pathways during development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RAC-beta serine/threonine-protein kinase

NP_937789.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198146.2 → NP_937789.1 RAC-beta serine/threonine-protein kinase

See identical proteins and their annotated locations for NP_937789.1

Status: PROVISIONAL

Source sequence(s)

BC125908

UniProtKB/TrEMBL

A0JMK1, F6NS69, Q1LVI3, Q8UUX0

Related

ENSDARP00000023119.7, ENSDART00000026767.9

Conserved Domains (4) summary

cd05595
Location:154 → 476

STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)

smart00220
Location:150 → 407

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

pfam00169
Location:6 → 106

PH; PH domain