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ITP Ion transport peptide [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37921, updated on 18-Sep-2024

Summary

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Official Symbol
ITPprovided by FlyBase
Official Full Name
Ion transport peptideprovided by FlyBase
Primary source
FLYBASE:FBgn0035023
Locus tag
Dmel_CG13586
See related
AllianceGenome:FB:FBgn0035023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:SD05282; CG13586; chgh; CHH-like; Dmel\CG13586; Drm-ITP; DrmITP; DrmITPL1; DrmITPL2; itp; Itp
Summary
Predicted to enable neuropeptide hormone activity. Involved in circadian sleep/wake cycle; locomotor rhythm; and neuropeptide signaling pathway. Predicted to be located in extracellular space. Is expressed in several structures, including abdominal segment 8; circulatory system; dorsal closure embryo; nervous system; and retrocerebral complex. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ITP in Genome Data Viewer
Location:
60D4-60D5; 2-107 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24537421..24558961)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20424944..20446484)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nucleosome remodeling factor - 38kD Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The thirsty fly: Ion transport peptide (ITP) is a novel endocrine regulator of water homeostasis in Drosophila. Gáliková M, et al. PLoS Genet, 2018 Aug. PMID 30138334, Free PMC Article
  2. Insect ion transport peptides are derived from alternatively spliced genes and differentially expressed in the central and peripheral nervous system. Dircksen H. J Exp Biol, 2009 Feb. PMID 19151215
  3. Ion transport peptide splice forms in central and peripheral neurons throughout postembryogenesis of Drosophila melanogaster. Dircksen H, et al. J Comp Neurol, 2008 Jul 1. PMID 18418898
  4. Ion transport peptide regulates energy intake, expenditure, and metabolic homeostasis in Drosophila. Gáliková M, et al. Genetics, 2022 Nov 30. PMID 36190340, Free PMC Article
  5. Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila. Zandawala M, et al. Cell Mol Life Sci, 2018 Mar. PMID 29043393, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel antidiuretic hormone governs tumour-induced renal dysfunction.
    Title: A novel antidiuretic hormone governs tumour-induced renal dysfunction.
  2. ITP responds to both osmotic and desiccation stress, and dysregulation of ITP signaling compromises the fly's ability to cope with these stressors.
    Title: The thirsty fly: Ion transport peptide (ITP) is a novel endocrine regulator of water homeostasis in Drosophila.
  3. This study demonistrated that the ion transport peptide is a new functional clock neuropeptide in the fruit fly Drosophila melanogaster.
    Title: The ion transport peptide is a new functional clock neuropeptide in the fruit fly Drosophila melanogaster.
  4. This paper describes the identification of three itp alternative splice forms and the biochemical identification of their corresponding ITPL1, ITPL2 and ITP neuropeptide isoforms.
    Title: Ion transport peptide splice forms in central and peripheral neurons throughout postembryogenesis of Drosophila melanogaster.
  5. We have demonstrated here that subsets of Drosophila lateral clock neurons are heterogeneous with respect to expression of neuroactive compounds, including ion transport peptide and short neuropeptide F
    Title: Peptidergic clock neurons in Drosophila: ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons.
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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hormone activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables neuropeptide hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide hormone activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in circadian sleep/wake cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in drinking behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organismal-level water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in neuropeptide signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of defecation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to desiccation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Ion transport peptide
Names
CG13586-PC
CG13586-PD
CG13586-PE
CG13586-PF
CG13586-PG
ION TRANSPORT PEPTIDE
ITP-PC
ITP-PD
ITP-PE
ITP-PF
ITP-PG
ion transport polypeptide

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24537421..24558961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299916.1 → NP_001286845.1  Ion transport peptide, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286845.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SV5, Q9W151
    Conserved Domains (1) summary
    pfam01147
    Location:37 → 103
    Crust_neurohorm; Crustacean CHH/MIH/GIH neurohormone family

  2. NM_138087.6 → NP_611931.3  Ion transport peptide, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611931.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SV5, Q9W151
    Conserved Domains (1) summary
    pfam01147
    Location:37 → 103
    Crust_neurohorm; Crustacean CHH/MIH/GIH neurohormone family

  3. NM_001169822.3 → NP_001163293.1  Ion transport peptide, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163293.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JGW3
    Conserved Domains (1) summary
    pfam01147
    Location:37 → 101
    Crust_neurohorm; Crustacean CHH/MIH/GIH neurohormone family

  4. NM_001043104.3 → NP_001036569.2  Ion transport peptide, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036569.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8W5
    Conserved Domains (1) summary
    pfam01147
    Location:37 → 104
    Crust_neurohorm; Crustacean CHH/MIH/GIH neurohormone family

  5. NM_001169823.2 → NP_001163294.1  Ion transport peptide, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163294.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SV5, Q9W151
    Conserved Domains (1) summary
    pfam01147
    Location:37 → 103
    Crust_neurohorm; Crustacean CHH/MIH/GIH neurohormone family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JGW3 E1JGW3
Q0E8W5 Q0E8W5
Q9W151 Q9W151

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