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Snx22 sorting nexin 22 [ Mus musculus (house mouse) ]

Gene ID: 382083, updated on 4-Jan-2025

Summary

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Official Symbol
Snx22provided by MGI
Official Full Name
sorting nexin 22provided by MGI
Primary source
MGI:MGI:2685966
See related
Ensembl:ENSMUSG00000039452 AllianceGenome:MGI:2685966
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1120
Summary
Predicted to enable phosphatidylinositol phosphate binding activity. Is expressed in several structures, including gut; liver; lung; male reproductive gland or organ; and sensory organ. Orthologous to human SNX22 (sorting nexin 22). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in placenta adult (RPKM 80.2), liver E18 (RPKM 56.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Snx22 in Genome Data Viewer
Location:
9 C; 9 35.69 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65972456..65977041, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66065174..66069759, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene STARR-seq mESC enhancer starr_24473 Neighboring gene PCNA clamp associated factor Neighboring gene predicted gene, 23248 Neighboring gene casein kinase 1, gamma 1 Neighboring gene predicted gene, 22657 Neighboring gene STARR-positive B cell enhancer mm9_chr9:65852147-65852448 Neighboring gene STARR-positive B cell enhancer ABC_E6757 Neighboring gene STARR-positive B cell enhancer ABC_E11412 Neighboring gene STARR-seq mESC enhancer starr_24475 Neighboring gene peptidylprolyl isomerase B Neighboring gene sorting nexin 1 Neighboring gene STARR-positive B cell enhancer ABC_E5080 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65974328-65974632 Neighboring gene cytosolic iron-sulfur assembly component 2A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Opposing Roles of Dendritic Cell Subsets in Experimental GN. Brähler S, et al. J Am Soc Nephrol, 2018 Jan. PMID 29217759, Free PMC Article
  2. Tibolone restrains neuroinflammation in mouse experimental autoimmune encephalomyelitis. Mancino DNJ, et al. J Neuroendocrinol, 2022 Jan. PMID 34961984
  3. Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer. Hegde S, et al. Cancer Cell, 2020 Mar 16. PMID 32183949, Free PMC Article
  4. High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity. Kim S, et al. Immunity, 2020 Oct 13. PMID 32795402, Free PMC Article
  5. cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory. Christian DA, et al. Sci Immunol, 2022 Sep 30. PMID 36179012, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
sorting nexin-22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025612.2 → NP_001020783.1  sorting nexin-22 isoform 1

    See identical proteins and their annotated locations for NP_001020783.1

    Status: VALIDATED

    Source sequence(s)
    AC112676
    Consensus CDS
    CCDS40671.1
    UniProtKB/TrEMBL
    Q8C084
    Related
    ENSMUSP00000044389.6, ENSMUST00000044711.7
    Conserved Domains (1) summary
    cd06880
    Location:2 → 115
    PX_SNX22; The phosphoinositide binding Phox Homology domain of Sorting Nexin 22

  2. NM_001379335.1 → NP_001366264.1  sorting nexin-22 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC112676
    Conserved Domains (1) summary
    cd06880
    Location:2 → 115
    PX_SNX22; The phosphoinositide binding Phox Homology domain of Sorting Nexin 22

  3. NM_001379336.1 → NP_001366265.1  sorting nexin-22 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC112676
    Conserved Domains (1) summary
    cl02563
    Location:2 → 80
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    65972456..65977041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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