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eif6 eukaryotic translation initiation factor 6 [ Danio rerio (zebrafish) ]

Gene ID: 386850, updated on 2-Nov-2024

Summary

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Official Symbol
eif6provided by ZNC
Official Full Name
eukaryotic translation initiation factor 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-031118-110
See related
Ensembl:ENSDARG00000020232 AllianceGenome:ZFIN:ZDB-GENE-031118-110
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
eIF-6; Itgb4bp; itgb4bp4; zgc:56562; wu:fc28a04; wu:ft88f05
Summary
Predicted to enable ribosomal large subunit binding activity. Predicted to be involved in ribosome biogenesis. Predicted to act upstream of or within ribosome biogenesis and translation. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alar plate midbrain region; immature eye; nervous system; neural plate; and segmental plate. Orthologous to human EIF6 (eukaryotic translation initiation factor 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See eif6 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (52339637..52348629, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (52339638..52348630, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 10 Neighboring gene extended synaptotagmin-like protein 1b Neighboring gene U2 spliceosomal RNA Neighboring gene si:ch211-239j9.1 Neighboring gene matrix metallopeptidase 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC56562

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in assembly of large subunit precursor of preribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytosolic ribosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cytosolic ribosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 6
Names
integrin beta 4 binding protein
NP_957238.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200944.1 → NP_957238.1  eukaryotic translation initiation factor 6

    See identical proteins and their annotated locations for NP_957238.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049488
    UniProtKB/Swiss-Prot
    Q6ZM19
    Related
    ENSDARP00000015326.7, ENSDART00000016890.9
    Conserved Domains (1) summary
    PTZ00136
    Location:1 → 244
    PTZ00136; eukaryotic translation initiation factor 6-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    52339637..52348629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZM19.1 GenPept UniProtKB/Swiss-Prot:Q6ZM19

Gene LinkOut

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