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VGLL3 vestigial like family member 3 [ Homo sapiens (human) ]

Gene ID: 389136, updated on 28-Oct-2024

Summary

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Official Symbol
VGLL3provided by HGNC
Official Full Name
vestigial like family member 3provided by HGNC
Primary source
HGNC:HGNC:24327
See related
Ensembl:ENSG00000206538 MIM:609980; AllianceGenome:HGNC:24327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VGL3; VGL-3
Summary
Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in placenta (RPKM 19.8), fat (RPKM 7.7) and 12 other tissues See more
Orthologs
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Genomic context

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See VGLL3 in Genome Data Viewer
Location:
3p12.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (86937973..86991149, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (87012305..87065510, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (86987123..87040299, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927518 Neighboring gene MPRA-validated peak4735 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:86925274-86925774 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:86940033-86940783 Neighboring gene uncharacterized LOC105377196 Neighboring gene MPRA-validated peak4737 silencer Neighboring gene MPRA-validated peak4738 silencer Neighboring gene phosphoribosyl pyrophosphate amidotransferase pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20109 Neighboring gene phosphoribosyl pyrophosphate amidotransferase pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 506

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases. Liang Y, et al. Nat Immunol, 2017 Feb. PMID 27992404, Free PMC Article
  2. Comparison of gene expression between normal colon mucosa and colon carcinoma by means of messenger RNA differential display. Wang L, et al. World J Gastroenterol, 1999 Dec. PMID 11819507, Free PMC Article
  3. Exploring the potential of VGLL3 methylation as a prognostic indicator for intracranial aneurysm with gender-specific considerations. Liu Y, et al. Biosci Rep, 2024 Mar 29. PMID 38348744, Free PMC Article
  4. VGLL3 is a prognostic biomarker and correlated with clinical pathologic features and immune infiltrates in stomach adenocarcinoma. Zhang L, et al. Sci Rep, 2020 Jan 28. PMID 31992826, Free PMC Article
  5. Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway. Hori N, et al. J Biol Chem, 2020 Jun 26. PMID 32385107, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exploring the potential of VGLL3 methylation as a prognostic indicator for intracranial aneurysm with gender-specific considerations.
    Title: Exploring the potential of VGLL3 methylation as a prognostic indicator for intracranial aneurysm with gender-specific considerations.
  2. VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation.
    Title: VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation.
  3. Recurrent VGLL3 fusions define a distinctive subset of spindle cell rhabdomyosarcoma with an indolent clinical course and striking predilection for the head and neck.
    Title: Recurrent VGLL3 fusions define a distinctive subset of spindle cell rhabdomyosarcoma with an indolent clinical course and striking predilection for the head and neck.
  4. Regulation of type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway.
    Title: Regulation of type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway.
  5. VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression.
    Title: VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression.
  6. Clinicopathologic and Molecular Study of Hybrid Nerve Sheath Tumors Reveals Their Common Association With Fusions Involving VGLL3.
    Title: Clinicopathologic and Molecular Study of Hybrid Nerve Sheath Tumors Reveals Their Common Association With Fusions Involving VGLL3.
  7. Hybrid schwannoma-perineurioma frequently harbors VGLL3 rearrangement.
    Title: Hybrid schwannoma-perineurioma frequently harbors VGLL3 rearrangement.
  8. VGLL3 activates inflammatory responses by inducing interleukin-1alpha secretion.
    Title: VGLL3 activates inflammatory responses by inducing interleukin-1α secretion.
  9. Immunometabolic function of the transcription cofactor VGLL3 provides an evolutionary rationale for sexual dimorphism in autoimmunity.
    Title: Immunometabolic function of the transcription cofactor VGLL3 provides an evolutionary rationale for sexual dimorphism in autoimmunity.
  10. A new perspective on the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors.
    Title: A new perspective on the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
EBI GWAS Catalog
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38507, DKFZp686O1845

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription cofactor vestigial-like protein 3
Names
colon carcinoma related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320493.2 → NP_001307422.1  transcription cofactor vestigial-like protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC108709, BC094780, DA828655
    Consensus CDS
    CCDS82807.1
    UniProtKB/Swiss-Prot
    A8MV65
    Related
    ENSP00000373199.3, ENST00000383698.3
    Conserved Domains (1) summary
    pfam07545
    Location:82 → 112
    Vg_Tdu; Vestigial/Tondu family

  2. NM_001320494.2 → NP_001307423.1  transcription cofactor vestigial-like protein 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC108709
    Conserved Domains (1) summary
    pfam07545
    Location:42 → 59
    Vg_Tdu; Vestigial/Tondu family

  3. NM_016206.4 → NP_057290.2  transcription cofactor vestigial-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_057290.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA455617, AC108709, AI379920, BC094780, DA828655, DB319377
    Consensus CDS
    CCDS43110.1
    UniProtKB/Swiss-Prot
    A8MV65, D3DU37, Q504T7
    Related
    ENSP00000381436.2, ENST00000398399.7
    Conserved Domains (1) summary
    pfam07545
    Location:82 → 112
    Vg_Tdu; Vestigial/Tondu family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    86937973..86991149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713138.5 → XP_006713201.1  transcription cofactor vestigial-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006713201.1

    Conserved Domains (1) summary
    pfam07545
    Location:81 → 111
    Vg_Tdu; Vestigial/Tondu family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    87012305..87065510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346475.1 → XP_054202450.1  transcription cofactor vestigial-like protein 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MV65.1 GenPept UniProtKB/Swiss-Prot:A8MV65

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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