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ctu1 cytosolic thiouridylase subunit 1 homolog (S. pombe) [ Danio rerio (zebrafish) ]

Gene ID: 393098, updated on 4-Jan-2025

Summary

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Official Symbol
ctu1provided by ZNC
Official Full Name
cytosolic thiouridylase subunit 1 homolog (S. pombe)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-704
See related
Ensembl:ENSDARG00000020986 Ensembl:ENSDARG00000100247 AllianceGenome:ZFIN:ZDB-GENE-040426-704
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55395
Summary
Predicted to enable tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to act upstream of or within lipid metabolic process and tRNA processing. Predicted to be located in cytosol. Predicted to be part of cytosolic tRNA wobble base thiouridylase complex. Orthologous to human CTU1 (cytosolic thiouridylase subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See ctu1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (3423203..3439484)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (3364373..3380735)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 9b, tandem duplicate 1 Neighboring gene fucosyltransferase 9b, tandem duplicate 3 Neighboring gene fucosyltransferase 9b, tandem duplicate 6 Neighboring gene fucosyltransferase 9b, tandem duplicate 4 Neighboring gene fucosyltransferase 9b, tandem duplicate 5 Neighboring gene paxillin b Neighboring gene GCN1 activator of EIF2AK4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Jiang L, et al. Cell, 2013 May 9. PMID 23663777, Free PMC Article
  2. Evolution and Expression of Paxillin Genes in Teleost Fish. Jacob AE, et al. PLoS One, 2016. PMID 27806088, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC55395

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein urmylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA thio-modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA thio-modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA thio-modification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA wobble position uridine thiolation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of cytosolic tRNA wobble base thiouridylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytoplasmic tRNA 2-thiolation protein 1
NP_956424.1
XP_005172497.3
XP_017212780.1
XP_068078993.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200130.1 → NP_956424.1  cytoplasmic tRNA 2-thiolation protein 1

    See identical proteins and their annotated locations for NP_956424.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044158
    UniProtKB/Swiss-Prot
    A8WGP6, A9JRT6, Q803X1
    UniProtKB/TrEMBL
    B2GNZ1
    Related
    ENSDARP00000009303.7, ENSDART00000017850.9
    Conserved Domains (3) summary
    TIGR00269
    Location:204 → 305
    TIGR00269; TIGR00269 family protein
    COG0037
    Location:28 → 312
    TilS; tRNA(Ile)-lysidine synthase TilS/MesJ [Translation, ribosomal structure and biogenesis]
    cd01993
    Location:53 → 240
    Alpha_ANH_like_II; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    3423203..3439484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005172440.5 → XP_005172497.3  cytoplasmic tRNA 2-thiolation protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BJT0

  2. XM_068222892.1 → XP_068078993.1  cytoplasmic tRNA 2-thiolation protein 1 isoform X2

    Related
    ENSDARP00000139431.1, ENSDART00000159466.2

  3. XM_017357291.3 → XP_017212780.1  cytoplasmic tRNA 2-thiolation protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z811
    Conserved Domains (2) summary
    pfam00852
    Location:190 → 367
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:66 → 172
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q803X1.1 GenPept UniProtKB/Swiss-Prot:Q803X1

Gene LinkOut

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