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cmtr1 cap methyltransferase 1 [ Danio rerio (zebrafish) ]

Gene ID: 393102, updated on 2-Nov-2024

Summary

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Official Symbol
cmtr1provided by ZNC
Official Full Name
cap methyltransferase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-696
See related
Ensembl:ENSDARG00000030830 AllianceGenome:ZFIN:ZDB-GENE-040426-696
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
MTr1; ftsjd2; zgc:55336
Summary
Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to act upstream of or within mRNA processing and methylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human CMTR1 (cap methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See cmtr1 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (35362780..35396871, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (35263863..35297957, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438306 Neighboring gene copine family member IX Neighboring gene uncharacterized LOC103909705 Neighboring gene uncharacterized LOC137489142 Neighboring gene si:ch211-225h24.2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. CMTr mediated 2'-O-ribose methylation status of cap-adjacent nucleotides across animals. Dix TC, et al. RNA, 2022 Oct. PMID 35970556, Free PMC Article
  2. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
  3. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC55336

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA (nucleoside-2'-O-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA (nucleoside-2'-O-)-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 7-methylguanosine mRNA capping IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within 7-methylguanosine mRNA capping IEA
Inferred from Electronic Annotation
more info
  
involved_in 7-methylguanosine mRNA capping IEA
Inferred from Electronic Annotation
more info
  
involved_in 7-methylguanosine mRNA capping ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA modification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Names
FtsJ methyltransferase domain containing 2
S-adenosyl-L-methionine-dependent methyltransferase ftsjd2
cap1 2'O-ribose methyltransferase 1
ftsJ methyltransferase domain-containing protein 2
NP_956427.1
XP_005162451.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200133.1 → NP_956427.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

    See identical proteins and their annotated locations for NP_956427.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044371
    UniProtKB/Swiss-Prot
    Q803R5
    Related
    ENSDARP00000049372.5, ENSDART00000049373.7
    Conserved Domains (4) summary
    smart00456
    Location:746 → 778
    WW; Domain with 2 conserved Trp (W) residues
    pfam01585
    Location:79 → 121
    G-patch; G-patch domain
    pfam01728
    Location:224 → 440
    FtsJ; FtsJ-like methyltransferase
    cl12015
    Location:547 → 709
    Adenylation_DNA_ligase_like; Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    35362780..35396871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162394.4 → XP_005162451.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B9K9, F1R5C5
    Related
    ENSDARP00000131572.1, ENSDART00000171357.3
    Conserved Domains (4) summary
    smart00456
    Location:746 → 778
    WW; Domain with 2 conserved Trp (W) residues
    pfam01585
    Location:79 → 121
    G-patch; G-patch domain
    pfam01728
    Location:224 → 440
    FtsJ; FtsJ-like methyltransferase
    cl12015
    Location:547 → 709
    Adenylation_DNA_ligase_like; Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q803R5.1 GenPept UniProtKB/Swiss-Prot:Q803R5

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