pex12 peroxisomal biogenesis factor 12 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pex12provided by ZNC
Official Full Name: peroxisomal biogenesis factor 12provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-929
See related: Ensembl:ENSDARG00000035149 AllianceGenome:ZFIN:ZDB-GENE-040426-929
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56182
Summary: Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein import into peroxisome matrix and protein monoubiquitination. Predicted to be located in membrane and peroxisome. Predicted to be part of peroxisomal importomer complex. Predicted to be active in peroxisomal membrane. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 3A and peroxisome biogenesis disorder 3B. Orthologous to human PEX12 (peroxisomal biogenesis factor 12). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (61583655..61588999, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (60898934..60904278, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein import into peroxisome matrix	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into peroxisome matrix	IEA Inferred from Electronic Annotation more info
involved_in protein monoubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of peroxisomal importomer complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peroxisome assembly protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200205.2 → NP_956499.2 peroxisome assembly protein 12

Status: VALIDATED

Source sequence(s)

EH457223, EH482945, EH530715

UniProtKB/TrEMBL

A0A8N7V001, B0R157

Related

ENSDARP00000050911.4, ENSDART00000050912.6

Conserved Domains (2) summary

pfam04757
Location:26 → 261

Pex2_Pex12; Pex2 / Pex12 amino terminal region

pfam13923
Location:295 → 332

zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)