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rbpms2b RNA binding protein, mRNA processing factor 2b [ Danio rerio (zebrafish) ]

Gene ID: 393229, updated on 4-Jan-2025

Summary

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Official Symbol
rbpms2bprovided by ZNC
Official Full Name
RNA binding protein, mRNA processing factor 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-741
See related
Ensembl:ENSDARG00000079578 AllianceGenome:ZFIN:ZDB-GENE-040426-741
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hermes; rbpms2; zgc:55559; zgc:77170
Summary
Enables mRNA binding activity. Acts upstream of or within several processes, including heart contraction; neuron projection morphogenesis; and regulation of retinal ganglion cell axon guidance. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; gonad; mesoderm; optic vesicle; and retina. Orthologous to human RBPMS2 (RNA binding protein, mRNA processing factor 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See rbpms2b in Genome Data Viewer
Location:
chromosome: 7
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (48252638..48263624, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (47979876..47990846, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene MTSS I-BAR domain containing 2b Neighboring gene cytoplasmic polyadenylation element binding protein 1b Neighboring gene solute carrier family 25 member 44b Neighboring gene ornithine decarboxylase antizyme 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Exploring the Activities of RBPMS Proteins in Myocardial Biology. Akerberg AA, et al. Pediatr Cardiol, 2019 Oct. PMID 31399780, Free PMC Article
  2. RNA-binding protein Hermes/RBPMS inversely affects synapse density and axon arbor formation in retinal ganglion cells in vivo. Hörnberg H, et al. J Neurosci, 2013 Jun 19. PMID 23785151, Free PMC Article
  3. Spatiotemporal localization of germ plasm RNAs during zebrafish oogenesis. Kosaka K, et al. Mech Dev, 2007 Apr. PMID 17293094
  4. Ptf1a is expressed transiently in all types of amacrine cells in the embryonic zebrafish retina. Jusuf PR, et al. Neural Dev, 2009 Sep 4. PMID 19732413, Free PMC Article
  5. Oocyte polarity requires a Bucky ball-dependent feedback amplification loop. Heim AE, et al. Development, 2014 Feb. PMID 24496621, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios.
    Title: Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios.
  2. RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function.
    Title: RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC55559

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dendrite morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within female sex differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within female sex differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of smooth muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of retinal ganglion cell axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within retinal ganglion cell axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA-binding protein with multiple splicing 2b
Names
RNA binding protein with multiple splicing 2
RNA binding protein with multiple splicing 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200259.1 → NP_956553.1  RNA-binding protein with multiple splicing 2b

    See identical proteins and their annotated locations for NP_956553.1

    Status: PROVISIONAL

    Source sequence(s)
    BC048876
    UniProtKB/TrEMBL
    F6NRR6, Q6NYY7, Q7ZUL7
    Conserved Domains (2) summary
    COG0724
    Location:4 → 83
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12683
    Location:19 → 94
    RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    48252638..48263624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017356826.3 → XP_017212315.1  RNA-binding protein with multiple splicing 2b isoform X1

    UniProtKB/TrEMBL
    F6NRR6, Q6NYY7, Q7ZUL7
    Conserved Domains (2) summary
    COG0724
    Location:4 → 83
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12683
    Location:19 → 94
    RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

  2. XM_017356825.3 → XP_017212314.1  RNA-binding protein with multiple splicing 2b isoform X1

    UniProtKB/TrEMBL
    F6NRR6, Q6NYY7, Q7ZUL7
    Related
    ENSDARP00000026087.6, ENSDART00000006619.8
    Conserved Domains (2) summary
    COG0724
    Location:4 → 83
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12683
    Location:19 → 94
    RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

  3. XM_068222193.1 → XP_068078294.1  RNA-binding protein with multiple splicing 2b isoform X1

    UniProtKB/TrEMBL
    F6NRR6, Q6NYY7, Q7ZUL7
    Related
    ENSDARP00000118336.1, ENSDART00000142370.3
Nucleotide Protein Strain
Heading Accession and Version

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