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psmd6 proteasome 26S subunit, non-ATPase 6 [ Danio rerio (zebrafish) ]

Gene ID: 393261, updated on 2-Nov-2024

Summary

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Official Symbol
psmd6provided by ZNC
Official Full Name
proteasome 26S subunit, non-ATPase 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1038
See related
Ensembl:ENSDARG00000070674 AllianceGenome:ZFIN:ZDB-GENE-040426-1038
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56471
Summary
Acts upstream of or within lens fiber cell differentiation and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle. Is expressed in ciliary marginal zone; head; and lens epithelium. Orthologous to human PSMD6 (proteasome 26S subunit, non-ATPase 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See psmd6 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (19502367..19511548)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (19340025..19349206)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene prickle homolog 2b Neighboring gene uncharacterized LOC137496690 Neighboring gene uncharacterized LOC137496745 Neighboring gene solute carrier family 2 member 9, like 1 Neighboring gene ataxin 7 Neighboring gene THO complex 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing. Nepal C, et al. Nat Commun, 2020 Jan 10. PMID 31924754, Free PMC Article
  2. The ubiquitin proteasome system is required for cell proliferation of the lens epithelium and for differentiation of lens fiber cells in zebrafish. Imai F, et al. Development, 2010 Oct. PMID 20724448
  3. A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Ayobahan SU, et al. Sci Rep, 2019 Apr 29. PMID 31036921, Free PMC Article
  4. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC56471

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within lens fiber cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 6
Names
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
vov

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200291.1 → NP_956585.1  26S proteasome non-ATPase regulatory subunit 6

    See identical proteins and their annotated locations for NP_956585.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049452
    UniProtKB/TrEMBL
    Q7ZWE5
    Related
    ENSDARP00000094762.2, ENSDART00000103987.3
    Conserved Domains (3) summary
    COG5187
    Location:15 → 379
    RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]
    pfam01399
    Location:251 → 355
    PCI; PCI domain
    pfam10602
    Location:63 → 236
    RPN7; 26S proteasome subunit RPN7

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    19502367..19511548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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