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stn1 STN1 subunit of CST complex [ Danio rerio (zebrafish) ]

Gene ID: 393360, updated on 14-Nov-2024

Summary

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Official Symbol
stn1provided by ZNC
Official Full Name
STN1 subunit of CST complexprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1390
See related
Ensembl:ENSDARG00000007734 AllianceGenome:ZFIN:ZDB-GENE-040426-1390
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
obfc1; zgc:64174
Summary
Predicted to enable single-stranded telomeric DNA binding activity. Acts upstream of or within vasculature development. Predicted to be located in nucleus. Predicted to be part of CST complex. Predicted to be active in chromosome, telomeric region. Used to study telangiectasis. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human STN1 (STN1 subunit of CST complex). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See stn1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (47499913..47513484)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (46808681..46822252)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 58a Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene SH3 and PX domains 2Aa Neighboring gene neuralized E3 ubiquitin protein ligase 1Aa Neighboring gene uncharacterized LOC137495818

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects. Simon AJ, et al. J Exp Med, 2016 Jul 25. PMID 27432940, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC64174

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded telomeric DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded telomeric DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within telomere capping IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in telomere maintenance via telomere lengthening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance via telomere lengthening ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CST complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CST complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
CST complex subunit STN1
Names
STN1, CST complex subunit
oligonucleotide/oligosaccharide-binding fold containing 1
oligonucleotide/oligosaccharide-binding fold-containing protein 1
suppressor of cdc thirteen homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200389.1 → NP_956683.1  CST complex subunit STN1

    See identical proteins and their annotated locations for NP_956683.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053298
    UniProtKB/Swiss-Prot
    B8JKF4, Q7T311
    Related
    ENSDARP00000013967.6, ENSDART00000027624.7
    Conserved Domains (2) summary
    cd04483
    Location:59 → 162
    hOBFC1_like; hOBFC1_like: A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which ...
    pfam09170
    Location:164 → 334
    STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    47499913..47513484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B8JKF4.1 GenPept UniProtKB/Swiss-Prot:B8JKF4

Gene LinkOut

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