wipi1 WD repeat domain, phosphoinositide interacting 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wipi1provided by ZNC
Official Full Name: WD repeat domain, phosphoinositide interacting 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1404
See related: Ensembl:ENSDARG00000040657 AllianceGenome:ZFIN:ZDB-GENE-040426-1404
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:64205
Summary: Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagy of mitochondrion and macroautophagy. Predicted to act upstream of or within autophagy. Predicted to be active in cytosol and phagophore assembly site membrane. Is expressed in central nervous system; notochord; and periderm. Orthologous to human WIPI1 (WD repeat domain, phosphoinositide interacting 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (36284981..36306403)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (36155371..36176805)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy of peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein lipidation involved in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat domain phosphoinositide-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200391.1 → NP_956685.1 WD repeat domain phosphoinositide-interacting protein 1

See identical proteins and their annotated locations for NP_956685.1

Status: PROVISIONAL

Source sequence(s)

BC053306

UniProtKB/TrEMBL

Q7T305

Related

ENSDARP00000059532.4, ENSDART00000059533.5

Conserved Domains (3) summary

COG2319
Location:102 → 276

WD40; WD40 repeat [General function prediction only]

sd00039
Location:147 → 186

7WD40; WD40 repeat [structural motif]

cl02567
Location:122 → 264

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

36284981..36306403

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164002.5 → XP_005164059.1 WD repeat domain phosphoinositide-interacting protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M2BBH4

Conserved Domains (3) summary

COG2319
Location:101 → 275

WD40; WD40 repeat [General function prediction only]

sd00039
Location:146 → 185

7WD40; WD40 repeat [structural motif]

cl02567
Location:121 → 263

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...