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tra2a transformer 2 alpha homolog [ Danio rerio (zebrafish) ]

Gene ID: 393388, updated on 4-Jan-2025

Summary

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Official Symbol
tra2aprovided by ZNC
Official Full Name
transformer 2 alpha homologprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1391
See related
Ensembl:ENSDARG00000007863 AllianceGenome:ZFIN:ZDB-GENE-040426-1391
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:64175
Summary
Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of mRNA splicing, via spliceosome. Predicted to be part of spliceosomal complex. Orthologous to human TRA2A (transformer 2 alpha homolog). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See tra2a in Genome Data Viewer
Location:
chromosome: 19
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (20177929..20190806)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (20593569..20606483)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 221 member A Neighboring gene coiled-coil domain containing 126 Neighboring gene uncharacterized LOC137488504 Neighboring gene insulin-like growth factor 2 mRNA binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish transcriptome during early development. Vesterlund L, et al. BMC Dev Biol, 2011 May 24. PMID 21609443, Free PMC Article
  2. Identification of nodal signaling targets by array analysis of induced complex probes. Dickmeis T, et al. Dev Dyn, 2001 Dec. PMID 11748827
  3. Phylogenetic and evolutionary relationships and developmental expression patterns of the zebrafish twist gene family. Yeo GH, et al. Dev Genes Evol, 2009 Jun. PMID 19565261
  4. An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. Fouchécourt S, et al. BMC Evol Biol, 2019 Jul 3. PMID 31269894, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC64175

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transformer-2 protein homolog alpha
Names
transformer-2 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200416.1 → NP_956710.1  transformer-2 protein homolog alpha

    See identical proteins and their annotated locations for NP_956710.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054632
    UniProtKB/TrEMBL
    A0A8M1PEF5, Q7T2A0
    Related
    ENSDARP00000010426.9, ENSDART00000008595.11
    Conserved Domains (2) summary
    COG0724
    Location:117 → 211
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12363
    Location:136 → 213
    RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    20177929..20190806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170010.5 → XP_005170067.1  transformer-2 protein homolog alpha isoform X2

    See identical proteins and their annotated locations for XP_005170067.1

    UniProtKB/TrEMBL
    A0A8M3ASI8
    Conserved Domains (2) summary
    COG0724
    Location:73 → 182
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12363
    Location:107 → 184
    RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  2. XM_009294204.4 → XP_009292479.1  transformer-2 protein homolog alpha isoform X2

    See identical proteins and their annotated locations for XP_009292479.1

    UniProtKB/TrEMBL
    A0A8M3ASI8
    Conserved Domains (2) summary
    COG0724
    Location:73 → 182
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12363
    Location:107 → 184
    RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  3. XM_005170007.5 → XP_005170064.1  transformer-2 protein homolog alpha isoform X1

    UniProtKB/TrEMBL
    A0A8M2BHB0
    Conserved Domains (2) summary
    COG0724
    Location:117 → 211
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12363
    Location:136 → 213
    RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
Nucleotide Protein
Heading Accession and Version

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