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cox6b2 cytochrome c oxidase subunit 6B2 [ Danio rerio (zebrafish) ]

Gene ID: 393478, updated on 15-Dec-2024

Summary

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Official Symbol
cox6b2provided by ZNC
Official Full Name
cytochrome c oxidase subunit 6B2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1566
See related
Ensembl:ENSDARG00000037860 AllianceGenome:ZFIN:ZDB-GENE-040426-1566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66195; si:ch73-70l21.2
Summary
Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrion. Is expressed in brain; gill; heart; liver; and skeletal muscle. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 7. Orthologous to several human genes including COX6B1 (cytochrome c oxidase subunit 6B1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See cox6b2 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (12504929..12512599, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (12614027..12621706, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene eph receptor B6 Neighboring gene solute carrier family 2 member 3b Neighboring gene uncharacterized LOC137487882 Neighboring gene Ras interacting protein 1 Neighboring gene interleukin 11a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptomic analysis reveals mitochondrial dysfunction in the pathogenesis of Nager syndrome in sf3b4-depleted zebrafish. Ulhaq ZS, et al. Biochim Biophys Acta Mol Basis Dis, 2024 Apr. PMID 38508476
  2. Coordination of cytochrome c oxidase gene expression in the remodelling of skeletal muscle. Duggan AT, et al. J Exp Biol, 2011 Jun 1. PMID 21562175
  3. Evolution of the nuclear-encoded cytochrome oxidase subunits in vertebrates. Little AG, et al. Physiol Genomics, 2010 Jun. PMID 20233836
  4. The important role of apolipoprotein A-II in ezetimibe driven reduction of high cholesterol diet-induced atherosclerosis. Yan Y, et al. Atherosclerosis, 2019 Jan. PMID 30500605
  5. asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. Cai W, et al. Int J Mol Sci, 2023 Nov 15. PMID 38003559, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC66195

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 6B2
Names
cytochrome c oxidase subunit VIb polypeptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282092.2 → NP_001269021.1  cytochrome c oxidase subunit 6B2

    See identical proteins and their annotated locations for NP_001269021.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    CU694256, EH549072
    UniProtKB/TrEMBL
    A0A8M1P064, Q7SXM1
    Related
    ENSDARP00000140452.1, ENSDART00000160906.3
    Conserved Domains (1) summary
    cd00926
    Location:8 → 85
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  2. NM_200506.3 → NP_956800.1  cytochrome c oxidase subunit 6B2

    See identical proteins and their annotated locations for NP_956800.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    CU694256, EH436037, EH549072
    UniProtKB/TrEMBL
    A0A8M1P064, Q7SXM1
    Related
    ENSDARP00000055160.3, ENSDART00000055161.5
    Conserved Domains (1) summary
    cd00926
    Location:8 → 85
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    12504929..12512599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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