U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pank4 pantothenate kinase 4 (inactive) [ Danio rerio (zebrafish) ]

Gene ID: 393487, updated on 14-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
pank4provided by ZNC
Official Full Name
pantothenate kinase 4 (inactive)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1592
See related
AllianceGenome:ZFIN:ZDB-GENE-040426-1592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66285
Summary
Predicted to enable pantothenate kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in cataract. Orthologous to human PANK4 (pantothenate kinase 4 (inactive)). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See pank4 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (15878343..15915789)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (15743708..15781154)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496681 Neighboring gene RAP1A, member of RAS oncogene family b Neighboring gene dorsal inhibitory axon guidance protein a Neighboring gene zgc:173544

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease. Zizioli D, et al. Neurobiol Dis, 2016 Jan. PMID 26476142, Free PMC Article
  2. Neucrin, a novel secreted antagonist of canonical Wnt signaling, plays roles in developing neural tissues in zebrafish. Miyake A, et al. Mech Dev, 2012 Jan-Feb. PMID 22265871
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC66285

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables pantothenate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
4'-phosphopantetheine phosphatase
NP_001315316.1
XP_005155852.1
XP_005155853.1
XP_068080227.1
XP_068080228.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328387.1 → NP_001315316.1  4'-phosphopantetheine phosphatase

    Status: VALIDATED

    Source sequence(s)
    FP003590
    UniProtKB/TrEMBL
    A0A8M1P4R1
    Conserved Domains (3) summary
    PLN02902
    Location:3 → 775
    PLN02902; pantothenate kinase
    pfam01937
    Location:453 → 766
    DUF89; Protein of unknown function DUF89
    pfam03630
    Location:35 → 364
    Fumble; Fumble

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    15878343..15915789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155795.5 → XP_005155852.1  4'-phosphopantetheine phosphatase isoform X1

    UniProtKB/TrEMBL
    A0A8M2B2I2
    Conserved Domains (3) summary
    PLN02902
    Location:3 → 773
    PLN02902; pantothenate kinase
    pfam01937
    Location:451 → 764
    DUF89; Protein of unknown function DUF89
    pfam03630
    Location:35 → 364
    Fumble; Fumble

  2. XM_005155796.5 → XP_005155853.1  4'-phosphopantetheine phosphatase isoform X2

    UniProtKB/TrEMBL
    A0A8M2B1X9
    Conserved Domains (3) summary
    PLN02902
    Location:3 → 769
    PLN02902; pantothenate kinase
    pfam01937
    Location:447 → 760
    DUF89; Protein of unknown function DUF89
    pfam03630
    Location:35 → 360
    Fumble; Fumble

  3. XM_068224126.1 → XP_068080227.1  4'-phosphopantetheine phosphatase isoform X3

  4. XM_068224127.1 → XP_068080228.1  4'-phosphopantetheine phosphatase isoform X4

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394809.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    51060..88506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_200515.1: Suppressed sequence

    Description
    NM_200515.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools