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irf7 interferon regulatory factor 7 [ Danio rerio (zebrafish) ]

Gene ID: 393650, updated on 2-Nov-2024

Summary

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Official Symbol
irf7provided by ZNC
Official Full Name
interferon regulatory factor 7provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1518
See related
Ensembl:ENSDARG00000045661 AllianceGenome:ZFIN:ZDB-GENE-040426-1518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66043; zgc:77947; wu:fl24c03
Summary
Enables transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including negative regulation of hematopoietic stem cell differentiation; neuromast hair cell development; and response to virus. Located in cytoplasm. Is expressed in several structures, including alar plate midbrain region; cardiovascular system; digestive system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See irf7 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (25546789..25550944, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (25451711..25455866, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489363 Neighboring gene microRNA 210 Neighboring gene PHD and ring finger domains 1 Neighboring gene hypermethylated in cancer 1 like Neighboring gene TBC1 domain family, member 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Fish ubiquitin-specific protease 8 (USP8) inhibits IFN production through autophagy-lysosomal dependent degradation of IRF7. Zhou CJ, et al. Dev Comp Immunol, 2024 Jul. PMID 38636698
  2. Characteristics of the interferon regulatory factor pairs zfIRF5/7 and their stimulation expression by ISKNV Infection in zebrafish (Danio rerio). Xiang Z, et al. Dev Comp Immunol, 2010 Dec. PMID 20637800
  3. Behavioural fever in zebrafish larvae. Rey S, et al. Dev Comp Immunol, 2017 Feb. PMID 27670815
  4. PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish. Zhao X, et al. Front Immunol, 2022. PMID 36172355, Free PMC Article
  5. Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis. Hu SQ, et al. Dev Neurobiol, 2022 Jan. PMID 34779143, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fish ubiquitin-specific protease 8 (USP8) inhibits IFN production through autophagy-lysosomal dependent degradation of IRF7.
    Title: Fish ubiquitin-specific protease 8 (USP8) inhibits IFN production through autophagy-lysosomal dependent degradation of IRF7.
  2. Zebrafish MAP2K7 Simultaneously Enhances Host IRF7 Stability and Degrades Spring Viremia of Carp Virus P Protein via Ubiquitination Pathway.
    Title: Zebrafish MAP2K7 Simultaneously Enhances Host IRF7 Stability and Degrades Spring Viremia of Carp Virus P Protein via Ubiquitination Pathway.
  3. Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis.
    Title: Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis.
  4. Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7.
    Title: Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7.
  5. Following spring viremia of carp virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp virus. data provide evidence that fish and mammals have evolved a similar IRF-dependent regulatory mechanism fine-tuning IFN gene activation.
    Title: Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFNΦ1 and IFNΦ3 Expression through Assembly of Homo- or Heteroprotein Complexes.
  6. Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7
    Title: Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7.
  7. The miR-142a-3p regulates HSC formation and differentiation through the repression of interferon regulatory factor 7 (irf7)-mediated inflammation signaling.
    Title: miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC66043

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables transcription regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within hemopoiesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of hematopoietic stem cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neuromast hair cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of T cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interferon regulatory factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313779.1 → NP_001300708.1  interferon regulatory factor 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in its 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL928892, EH494710, EH521037
    UniProtKB/TrEMBL
    A0A8M1P7R4, H0WFC4
    Related
    ENSDARP00000125556.1, ENSDART00000150412.3
    Conserved Domains (2) summary
    pfam00605
    Location:9 → 108
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:171 → 343
    IRF-3; Interferon-regulatory factor 3

  2. NM_200677.2 → NP_956971.2  interferon regulatory factor 7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
    Source sequence(s)
    AL928892, EH494710, EH521037
    UniProtKB/TrEMBL
    A0A8M1PFL5, F1QNG2
    Related
    ENSDARP00000094398.3, ENSDART00000103622.5
    Conserved Domains (2) summary
    pfam00605
    Location:9 → 108
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:216 → 388
    IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    25546789..25550944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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