rpe65a retinoid isomerohydrolase RPE65 a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rpe65aprovided by ZNC
Official Full Name: retinoid isomerohydrolase RPE65 aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1717
See related: Ensembl:ENSDARG00000007480 AllianceGenome:ZFIN:ZDB-GENE-040426-1717
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rpepa; RPE56a; zgc:73213
Summary: Predicted to enable all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity; beta-carotene 15,15'-dioxygenase activity; and retinol isomerase activity. Predicted to be involved in retinal metabolic process and zeaxanthin biosynthetic process. Predicted to act upstream of or within visual perception. Predicted to be located in endoplasmic reticulum membrane. Is expressed in head and visual system. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Orthologous to human RPE65 (retinoid isomerohydrolase RPE65). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (1428617..1443411, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (2316199..2330993, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, we developed a zebrafish transgenic model (rpe65a:nfsB-eGFP) that enabled ablation of large swathes of mature RPE. RPE ablation resulted in rapid RPE degeneration, as well as degeneration of Bruch's membrane and underlying photoreceptors. Using this model, we demonstrate for the first time that zebrafish are capable of regenerating a functional RPE monolayer after RPE ablation.
Title: Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	IEA Inferred from Electronic Annotation more info
enables all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity	IEA Inferred from Electronic Annotation more info
enables beta-carotene 15,15'-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info
enables retinol isomerase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in retinal metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info
involved_in zeaxanthin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinoid isomerohydrolase

Names: all-trans-retinylester 11-cis isomerohydrolase A; lutein isomerase; meso-zeaxanthin isomerase; retinal pigment epithelium 65a; retinal pigment epithelium-specific 65 kDa protein homolog A; retinal pigment epithelium-specific protein 65a; retinal pigment epithelium-specific protein a

NP_957045.1

EC 3.1.1.64

EC 5.3.3.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.