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gne glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase [ Danio rerio (zebrafish) ]

Gene ID: 393857, updated on 2-Nov-2024

Summary

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Official Symbol
gneprovided by ZNC
Official Full Name
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1848
See related
Ensembl:ENSDARG00000099771 AllianceGenome:ZFIN:ZDB-GENE-040426-1848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:77657
Summary
Enables UDP-N-acetylglucosamine 2-epimerase activity. Acts upstream of or within chordate embryonic development; locomotion; and muscle cell development. Is expressed in digestive system; muscle; nervous system; and somite border. Human ortholog(s) of this gene implicated in GNE myopathy; sialuria; and thrombocytopenia. Orthologous to human GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See gne in Genome Data Viewer
Location:
chromosome: 1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (12295168..12334540)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (11608458..11647740)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene tropomodulin 1 Neighboring gene complexin 2a Neighboring gene N-acetylneuraminic acid synthase a Neighboring gene clathrin, light chain A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Gne depletion during zebrafish development impairs skeletal muscle structure and function. Daya A, et al. Hum Mol Genet, 2014 Jul 1. PMID 24488768
  2. Generation and characterization of a novel gne Knockout Model in Zebrafish. Livne H, et al. Front Cell Dev Biol, 2022. PMID 36353515, Free PMC Article
  3. Rmrp Mutation Disrupts Chondrogenesis and Bone Ossification in Zebrafish Model of Cartilage-Hair Hypoplasia via Enhanced Wnt/β-Catenin Signaling. Sun X, et al. J Bone Miner Res, 2019 Nov. PMID 31237961
  4. Gene Characterization of Nocturnin Paralogues in Goldfish: Full Coding Sequences, Structure, Phylogeny and Tissue Expression. Madera D, et al. Int J Mol Sci, 2023 Dec 19. PMID 38203224, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC77657

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables N-acylmannosamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylglucosamine 2-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylglucosamine 2-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within UDP-N-acetylglucosamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
NP_957177.2
XP_068070496.1
XP_068070512.1
XP_068070519.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200883.2 → NP_957177.2  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

    Status: VALIDATED

    Source sequence(s)
    CR388406, CU915769
    Related
    ENSDARP00000137331.1, ENSDART00000158595.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    12295168..12334540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068214418.1 → XP_068070519.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X3

  2. XM_068214395.1 → XP_068070496.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X1

  3. XM_068214411.1 → XP_068070512.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X2

    Related
    ENSDARP00000133094.2, ENSDART00000164045.2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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