U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

sulf2a sulfatase 2a [ Danio rerio (zebrafish) ]

Gene ID: 393910, updated on 17-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
sulf2aprovided by ZNC
Official Full Name
sulfatase 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-759
See related
Ensembl:ENSDARG00000018423 AllianceGenome:ZFIN:ZDB-GENE-040426-759
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Sulf1; sulf2; zgc:55612
Summary
Predicted to enable N-acetylglucosamine-6-sulfatase activity and glycosaminoglycan binding activity. Acts upstream of or within with a positive effect on epithelial structure maintenance. Predicted to be located in Golgi stack and extracellular space. Predicted to be active in cell surface; endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including central nervous system; head; hypochord; neural plate; and neural tube. Orthologous to human SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See sulf2a in Genome Data Viewer
Location:
chromosome: 11
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (24907469..24993225)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (24669853..24755609)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene leiomodin 1b (smooth muscle) Neighboring gene translocase of inner mitochondrial membrane 17 homolog A (yeast) Neighboring gene Rho GTPase activating protein 46a Neighboring gene PHD finger protein 20, a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dynamic expression patterns of 6-O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2. Gorsi B, et al. Dev Dyn, 2010 Dec. PMID 20981828
  2. Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord. Danesin C, et al. Sci Rep, 2021 Jan 8. PMID 33420239, Free PMC Article
  3. Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish. Schenk H, et al. Biomed Res Int, 2019. PMID 31428635, Free PMC Article
  4. Evolution and genomic organization of muscle microRNAs in fish genomes. Nachtigall PG, et al. BMC Evol Biol, 2014 Sep 25. PMID 25253178, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord.
    Title: Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord.
  2. Sulf2 expression is almost entirely restricted to the CNS.
    Title: Dynamic expression patterns of 6-O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC55612

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables N-acetylglucosamine-6-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arylsulfatase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sulfuric ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bone development IEA
Inferred from Electronic Annotation
more info
  
involved_in chondrocyte development IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic skeletal system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within_positive_effect epithelial structure maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within_positive_effect epithelial structure maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in esophagus smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in glial cell-derived neurotrophic factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in glomerular basement membrane development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparan sulfate proteoglycan metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innervation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within_positive_effect oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of vascular endothelial growth factor production IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within_negative_effect ventral spinal cord interneuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
extracellular sulfatase Sulf-2a
Names
sulfatase 2
NP_957230.1
XP_005169326.1
XP_005169327.1
XP_021335240.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200936.1 → NP_957230.1  extracellular sulfatase Sulf-2a precursor

    See identical proteins and their annotated locations for NP_957230.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045403
    UniProtKB/TrEMBL
    Q7ZVU8
    Related
    ENSDARP00000009647.9, ENSDART00000008038.11
    Conserved Domains (3) summary
    pfam12548
    Location:541 → 670
    DUF3740; Sulfatase protein
    cd16147
    Location:45 → 387
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:757 → 806
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    24907469..24993225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169269.5 → XP_005169326.1  extracellular sulfatase Sulf-2a isoform X1

    See identical proteins and their annotated locations for XP_005169326.1

    UniProtKB/TrEMBL
    A0A8M2BGI3
    Conserved Domains (3) summary
    pfam12548
    Location:541 → 670
    DUF3740; Sulfatase protein
    cd16147
    Location:45 → 387
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:758 → 807
    ALP_like; alkaline phosphatases and sulfatases

  2. XM_021479565.2 → XP_021335240.1  extracellular sulfatase Sulf-2a isoform X2

    UniProtKB/TrEMBL
    A0A8M9QLI6
    Conserved Domains (3) summary
    cd16147
    Location:45 → 387
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:539 → 671
    DUF3740; Sulfatase protein
    cl23718
    Location:757 → 806
    ALP_like; alkaline phosphatases and sulfatases

  3. XM_005169270.5 → XP_005169327.1  extracellular sulfatase Sulf-2a isoform X1

    See identical proteins and their annotated locations for XP_005169327.1

    UniProtKB/TrEMBL
    A0A8M2BGI3
    Conserved Domains (3) summary
    pfam12548
    Location:541 → 670
    DUF3740; Sulfatase protein
    cd16147
    Location:45 → 387
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:758 → 807
    ALP_like; alkaline phosphatases and sulfatases

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394821.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    88784..178943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools